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Khdrbs3 KH domain containing, RNA binding, signal transduction associated 3 [ Mus musculus (house mouse) ]

Gene ID: 13992, updated on 12-May-2024

Summary

Official Symbol
Khdrbs3provided by MGI
Official Full Name
KH domain containing, RNA binding, signal transduction associated 3provided by MGI
Primary source
MGI:MGI:1313312
See related
Ensembl:ENSMUSG00000022332 AllianceGenome:MGI:1313312
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Etle; Salp; Slm2; SLM-2; T-STAR
Summary
Predicted to enable RNA binding activity; identical protein binding activity; and protein domain specific binding activity. Involved in regulation of mRNA splicing, via spliceosome. Located in nucleoplasm. Is expressed in several structures, including brain; genitourinary system; lung; sensory organ; and stomach. Orthologous to human KHDRBS3 (KH RNA binding domain containing, signal transduction associated 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 36.8), cortex adult (RPKM 31.0) and 19 other tissues See more
Orthologs
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Genomic context

See Khdrbs3 in Genome Data Viewer
Location:
15 D3; 15 30.36 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (68800155..68973064)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (68928392..69101794)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_38912 Neighboring gene predicted gene, 41341 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38913 Neighboring gene predicted gene, 31550 Neighboring gene RIKEN cDNA 4930573C08 gene Neighboring gene RIKEN cDNA 4930504C09 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (8)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
KH domain-containing, RNA-binding, signal transduction-associated protein 3
Names
RNA-binding protein Etoile
etoile
sam68-like mammalian protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411210.1NP_001398139.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123936
  2. NM_010158.3NP_034288.2  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_034288.2

    Status: VALIDATED

    Source sequence(s)
    AC123936
    Consensus CDS
    CCDS27513.1
    UniProtKB/Swiss-Prot
    O88624, Q9R226
    Related
    ENSMUSP00000022954.7, ENSMUST00000022954.7
    Conserved Domains (3) summary
    cd02395
    Location:58177
    SF1_like-KH; Splicing factor 1 (SF1) K homology RNA-binding domain (KH). Splicing factor 1 (SF1) specifically recognizes the intron branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts during spliceosome assembly. We show that the KH-QUA2 region of SF1 ...
    pfam16274
    Location:553
    Qua1; Qua1 domain
    pfam16568
    Location:266320
    Sam68-YY; Tyrosine-rich domain of Sam68

RNA

  1. NR_177197.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123936
  2. NR_177198.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC123936

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    68800155..68973064
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159122.1XP_036015015.1  KH domain-containing, RNA-binding, signal transduction-associated protein 3 isoform X1

    Conserved Domains (3) summary
    pfam16274
    Location:453
    Qua1; Qua1 domain
    pfam16568
    Location:266308
    Sam68-YY; Tyrosine-rich domain of Sam68
    cd22470
    Location:48160
    KH-I_KHDRBS3; type I K homology (KH) RNA-binding domain found in KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) and similar proteins