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GPR119 G protein-coupled receptor 119 [ Homo sapiens (human) ]

Gene ID: 139760, updated on 18-Sep-2018

Summary

Official Symbol
GPR119provided by HGNC
Official Full Name
G protein-coupled receptor 119provided by HGNC
Primary source
HGNC:HGNC:19060
See related
Ensembl:ENSG00000147262 MIM:300513; Vega:OTTHUMG00000022397
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR2
Summary
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
Orthologs

Genomic context

See GPR119 in Genome Data Viewer
Location:
Xq26.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (130384345..130385537, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129518319..129519511, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SNRPN upstream reading frame protein pseudogene Neighboring gene solute carrier family 25 member 14 Neighboring gene RNA binding motif protein X-linked 2 Neighboring gene fibrous sheath interacting protein 2 pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Incretin synthesis, secretion, and inactivation, organism-specific biosystem (from REACTOME)
    Incretin synthesis, secretion, and inactivation, organism-specific biosystemIncretins are peptide hormones produced by the gut that enhance the ability of glucose to stimulate insulin secretion from beta cells in the pancreas. Two incretins have been identified: Glucagon-lik...
  • Insulin secretion, organism-specific biosystem (from KEGG)
    Insulin secretion, organism-specific biosystemPancreatic beta cells are specialised endocrine cells that continuously sense the levels of blood sugar and other fuels and, in response, secrete insulin to maintain normal fuel homeostasis. Glucose-...
  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Peptide hormone metabolism, organism-specific biosystem (from REACTOME)
    Peptide hormone metabolism, organism-specific biosystemPeptide hormones are cleaved from larger precursors in the secretory system (endoplasmic reticulum, Golgi apparatus, secretory granules) of the cell. After secretion peptide hormones are modified and...
  • Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystem (from REACTOME)
    Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1), organism-specific biosystemIn L cells of the intestine the transcription factors TCF-4 (TCF7L2) and Beta-catenin form a heterodimer and bind the G2 enhancer of the Proglucagon gene GCG,activating its transcription to yield Pro...
  • Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystem (from REACTOME)
    Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP), organism-specific biosystemIn K cells of the intestine the transcription factors PAX6 and PDX-1 activate transcription of the gene encoding Glucose-dependent Insulinotropic Polypeptide (GIP, first called Gastric Inhibitory Pep...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119957

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
phosphatidylcholine binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin secretion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glucose-dependent insulinotropic receptor
Names
G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016404.1 RefSeqGene

    Range
    5001..6193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178471.2NP_848566.1  glucose-dependent insulinotropic receptor

    See identical proteins and their annotated locations for NP_848566.1

    Status: REVIEWED

    Source sequence(s)
    BC126179
    Consensus CDS
    CCDS14625.1
    UniProtKB/Swiss-Prot
    Q8TDV5
    Related
    ENSP00000276218.2, OTTHUMP00000024018, ENST00000276218.3, OTTHUMT00000058270
    Conserved Domains (1) summary
    cd15104
    Location:6290
    7tmA_GPR119_R_insulinotropic_receptor; G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    130384345..130385537 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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