Format

Send to:

Choose Destination

GPR119 G protein-coupled receptor 119 [ Homo sapiens (human) ]

Gene ID: 139760, updated on 13-Jun-2021

Summary

Official Symbol
GPR119provided by HGNC
Official Full Name
G protein-coupled receptor 119provided by HGNC
Primary source
HGNC:HGNC:19060
See related
Ensembl:ENSG00000147262 MIM:300513
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR2
Summary
This gene encodes a member of the rhodopsin subfamily of G-protein-coupled receptors that is expressed in the pancreas and gastrointestinal tract. The encoded protein is activated by lipid amides including lysophosphatidylcholine and oleoylethanolamide and may be involved in glucose homeostasis. This protein is a potential drug target in the treatment of type 2 diabetes.[provided by RefSeq, Jan 2010]
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR119 in Genome Data Viewer
Location:
Xq26.1
Exon count:
2
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (130379449..130385674, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (129513423..129519648, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SNRPN upstream reading frame protein pseudogene Neighboring gene solute carrier family 25 member 14 Neighboring gene RNA binding motif protein X-linked 2 Neighboring gene fibrous sheath interacting protein 2 like, pseudogene

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119957

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
glucose-dependent insulinotropic receptor
Names
G-protein coupled receptor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016404.1 RefSeqGene

    Range
    5001..6193
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178471.3NP_848566.1  glucose-dependent insulinotropic receptor

    See identical proteins and their annotated locations for NP_848566.1

    Status: REVIEWED

    Source sequence(s)
    AL035423
    Consensus CDS
    CCDS14625.1
    UniProtKB/Swiss-Prot
    Q8TDV5
    Related
    ENSP00000508182.1, ENST00000682440.1
    Conserved Domains (1) summary
    cd15104
    Location:6290
    7tmA_GPR119_R_insulinotropic_receptor; G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    130379449..130385674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center