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CRIP2 cysteine rich protein 2 [ Homo sapiens (human) ]

Gene ID: 1397, updated on 5-Aug-2018

Summary

Official Symbol
CRIP2provided by HGNC
Official Full Name
cysteine rich protein 2provided by HGNC
Primary source
HGNC:HGNC:2361
See related
Ensembl:ENSG00000182809 MIM:601183; Vega:OTTHUMG00000029906
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRIP; CRP2; ESP1
Summary
This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Expression
Broad expression in heart (RPKM 55.7), lung (RPKM 26.3) and 23 other tissues See more
Orthologs

Genomic context

See CRIP2 in Genome Data Viewer
Location:
14q32.33
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (105472938..105480170)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105939275..105946507)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100507437 Neighboring gene metastasis associated 1 Neighboring gene cysteine rich protein 1 Neighboring gene tubulin epsilon and delta complex 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cysteine-rich protein 2
Names
Cysteine-rich intestinal protein
LIM domain protein ESP1/CRP2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270837.1NP_001257766.1  cysteine-rich protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001257766.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate upstream start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AK300092, AL928654, AW173606, BC034151, HY161884
    Consensus CDS
    CCDS59246.1
    UniProtKB/Swiss-Prot
    P52943
    Related
    ENSP00000426119.2, OTTHUMP00000218028, ENST00000483017.7, OTTHUMT00000074599
    Conserved Domains (2) summary
    cd09401
    Location:200253
    LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
    cl02475
    Location:89132
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001270841.1NP_001257770.1  cysteine-rich protein 2 isoform 3

    See identical proteins and their annotated locations for NP_001257770.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks multiple exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AL928654, AW173606, BC034151, BQ684851
    UniProtKB/Swiss-Prot
    P52943
    Related
    ENSP00000446875.1, OTTHUMP00000243767, ENST00000550577.5, OTTHUMT00000409075
    Conserved Domains (1) summary
    cd09476
    Location:558
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
  3. NM_001312.3NP_001303.1  cysteine-rich protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL928654, AW173606, BC034151
    Consensus CDS
    CCDS10003.1
    UniProtKB/Swiss-Prot
    P52943
    Related
    ENSP00000328521.4, OTTHUMP00000028464, ENST00000329146.8, OTTHUMT00000074597
    Conserved Domains (1) summary
    cd09476
    Location:558
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)

RNA

  1. NR_073081.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL928654, AW173606, BC034151, HY078632
  2. NR_073082.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AL928654, AW173606, BC034151, BE271979, HY161884
  3. NR_073083.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because it lacks a portion of the coding region, compared to variant 1.
    Source sequence(s)
    AL928654, AW173606, BC034151, CN367966
    Related
    ENST00000538259.2, OTTHUMT00000409076
  4. NR_073084.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AK091845, AW173606
    Related
    ENST00000548989.5
  5. NR_073085.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks an in-frame ORF, compared to variant 1.
    Source sequence(s)
    AK311402, AL928654, AW173606, BC034151

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    105472938..105480170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024449480.1XP_024305248.1  cysteine-rich protein 2 isoform X1

    Conserved Domains (2) summary
    cd09401
    Location:126171
    LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
    cd09476
    Location:558
    LIM1_TLP; The first LIM domain of thymus LIM protein (TLP)
  2. XM_024449481.1XP_024305249.1  cysteine-rich protein 2 isoform X2

    Conserved Domains (3) summary
    cd09401
    Location:152205
    LIM_TLP_like; The LIM domains of thymus LIM protein (TLP)
    cl02475
    Location:6784
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    cl25983
    Location:22143
    Rnc; dsRNA-specific ribonuclease [Transcription]

RNA

  1. XR_002957531.1 RNA Sequence

    Related
    ENST00000552643.5
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