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FOXR2 forkhead box R2 [ Homo sapiens (human) ]

Gene ID: 139628, updated on 18-Sep-2022

Summary

Official Symbol
FOXR2provided by HGNC
Official Full Name
forkhead box R2provided by HGNC
Primary source
HGNC:HGNC:30469
See related
Ensembl:ENSG00000189299 MIM:300949; AllianceGenome:HGNC:30469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FOXN6
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See FOXR2 in Genome Data Viewer
Location:
Xp11.21
Exon count:
1
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (55623400..55626192)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (54916575..54919367)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (55649833..55652625)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MAGE family member E1 pseudogene Neighboring gene PSMA5 pseudogene 1 Neighboring gene X antigen family member 3-like Neighboring gene XAGE-4 protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC21658

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
forkhead box protein R2
Names
forkhead box protein N6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021325.1 RefSeqGene

    Range
    5001..7793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198451.4NP_940853.1  forkhead box protein R2

    See identical proteins and their annotated locations for NP_940853.1

    Status: VALIDATED

    Source sequence(s)
    AL159987, BC012934
    Consensus CDS
    CCDS35308.1
    UniProtKB/Swiss-Prot
    Q6PJQ5
    Related
    ENSP00000427329.2, ENST00000339140.5
    Conserved Domains (1) summary
    cd00059
    Location:192273
    FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    55623400..55626192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    54916575..54919367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)