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CRIP1 cysteine rich protein 1 [ Homo sapiens (human) ]

Gene ID: 1396, updated on 8-Dec-2018

Summary

Official Symbol
CRIP1provided by HGNC
Official Full Name
cysteine rich protein 1provided by HGNC
Primary source
HGNC:HGNC:2360
See related
Ensembl:ENSG00000213145 MIM:123875
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRHP; CRIP; CRP1; CRP-1
Summary
Cysteine-rich intestinal protein (CRIP) belongs to the LIM/double zinc finger protein family, members of which include cysteine- and glycine-rich protein-1 (CSRP1; MIM 123876), rhombotin-1 (RBTN1; MIM 186921), rhombotin-2 (RBTN2; MIM 180385), and rhombotin-3 (RBTN3; MIM 180386). CRIP may be involved in intestinal zinc transport (Hempe and Cousins, 1991 [PubMed 1946385]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in small intestine (RPKM 154.6), lung (RPKM 120.1) and 20 other tissues See more
Orthologs

Genomic context

See CRIP1 in Genome Data Viewer
Location:
14q32.33
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 14 NC_000014.9 (105486920..105488789)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (105952892..105955128)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene metastasis associated 1 Neighboring gene cysteine rich protein 2 Neighboring gene tubulin epsilon and delta complex 1 Neighboring gene transmembrane protein 121

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40971

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AT DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA binding, bending IDA
Inferred from Direct Assay
more info
PubMed 
peptide binding IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cellular response to UV-B IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to antibiotic IDA
Inferred from Direct Assay
more info
PubMed 
heart development TAS
Traceable Author Statement
more info
PubMed 
immune response IEP
Inferred from Expression Pattern
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
prostate gland stromal morphogenesis IEP
Inferred from Expression Pattern
more info
PubMed 
regulation of gene expression IEP
Inferred from Expression Pattern
more info
PubMed 
response to organic substance IEP
Inferred from Expression Pattern
more info
PubMed 
response to zinc ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cysteine-rich protein 1
Names
cysteine-rich heart protein
cysteine-rich intestinal protein
cysteine-rich protein 1 (intestinal)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311.4NP_001302.1  cysteine-rich protein 1

    See identical proteins and their annotated locations for NP_001302.1

    Status: VALIDATED

    Source sequence(s)
    BC002738, BQ128075, BU500642
    Consensus CDS
    CCDS10004.1
    UniProtKB/Swiss-Prot
    P50238
    Related
    ENSP00000376315.3, ENST00000392531.3
    Conserved Domains (1) summary
    cd09478
    Location:457
    LIM_CRIP; The LIM domain of Cysteine-Rich Intestinal Protein (CRIP)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p12 Primary Assembly

    Range
    105486920..105488789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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