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MAGEE2 MAGE family member E2 [ Homo sapiens (human) ]

Gene ID: 139599, updated on 23-Nov-2021

Summary

Official Symbol
MAGEE2provided by HGNC
Official Full Name
MAGE family member E2provided by HGNC
Primary source
HGNC:HGNC:24935
See related
Ensembl:ENSG00000186675 MIM:300760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA3
Summary
This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]
Orthologs
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Genomic context

See MAGEE2 in Genome Data Viewer
Location:
Xq13.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (75782987..75785254, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (75002822..75005089, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985664 Neighboring gene BRAF pseudogene 1 Neighboring gene tetratricopeptide repeat domain 3 pseudogene 1 Neighboring gene secretion associated Ras related GTPase 1A pseudogene 4 Neighboring gene FOXN3 pseudogene 2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138154

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen E2
Names
MAGE-E2 antigen
hepatocellular carcinoma-associated protein 3
hepatocellular carcinoma-associated protein HCA3
melanoma antigen family E, 2
melanoma antigen family E2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021324.1 RefSeqGene

    Range
    4991..7258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138703.5NP_619648.1  melanoma-associated antigen E2

    See identical proteins and their annotated locations for NP_619648.1

    Status: REVIEWED

    Source sequence(s)
    AK094624, AL391495, DA793762
    Consensus CDS
    CCDS14431.1
    UniProtKB/Swiss-Prot
    Q8TD90
    Related
    ENSP00000362457.2, ENST00000373359.4
    Conserved Domains (1) summary
    pfam01454
    Location:124264
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    75782987..75785254 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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