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OTUD6A OTU deubiquitinase 6A [ Homo sapiens (human) ]

Gene ID: 139562, updated on 23-Nov-2021

Summary

Official Symbol
OTUD6Aprovided by HGNC
Official Full Name
OTU deubiquitinase 6Aprovided by HGNC
Primary source
HGNC:HGNC:32312
See related
Ensembl:ENSG00000189401 MIM:300714
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DUBA2; HSHIN6
Summary
Deubiquitinating enzymes (DUBs; see MIM 603478) are proteases that specifically cleave ubiquitin (MIM 191339) linkages, negating the action of ubiquitin ligases. DUBA2 belongs to a DUB subfamily characterized by an ovarian tumor (OTU) domain.[supplied by OMIM, May 2008]
Orthologs
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Genomic context

See OTUD6A in Genome Data Viewer
Location:
Xq13.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (70062457..70064179)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (69282307..69284029)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ectodysplasin A Neighboring gene microRNA 676 Neighboring gene acyl-CoA wax alcohol acyltransferase 2 Neighboring gene MT-CYB pseudogene 31 Neighboring gene MT-ND6 pseudogene 31

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ25831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables thiol-dependent deubiquitinase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables thiol-dependent deubiquitinase IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein K11-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K11-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K27-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K27-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K29-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K29-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K33-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein K33-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
OTU domain-containing protein 6A
Names
HIN-6 protease
NP_997203.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207320.3NP_997203.1  OTU domain-containing protein 6A

    See identical proteins and their annotated locations for NP_997203.1

    Status: VALIDATED

    Source sequence(s)
    AK098697, AL158141
    Consensus CDS
    CCDS14395.1
    UniProtKB/Swiss-Prot
    Q7L8S5
    Related
    ENSP00000339389.2, ENST00000338352.3
    Conserved Domains (2) summary
    COG5539
    Location:5271
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:147269
    OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    70062457..70064179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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