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DCAF8L1 DDB1 and CUL4 associated factor 8 like 1 [ Homo sapiens (human) ]

Gene ID: 139425, updated on 11-Jun-2021

Summary

Official Symbol
DCAF8L1provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 8 like 1provided by HGNC
Primary source
HGNC:HGNC:31810
See related
Ensembl:ENSG00000226372
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR42B
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate the formation of heterotrimeric or multi-protein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene appears to represent an intronless retrocopy of a related multi-exon gene located on chromosome 1. However, the CDS of this intronless gene remains intact, it is conserved in other primate species, it is known to be transcribed, and it is therefore thought to encode a functional protein. [provided by RefSeq, May 2010]
Orthologs
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Genomic context

See DCAF8L1 in Genome Data Viewer
Location:
Xp21.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (27977992..27981449, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (27996109..27999566, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene VKORC1 pseudogene 1 Neighboring gene ORC1 pseudogene 1 Neighboring gene uncharacterized LOC105373151 Neighboring gene uncharacterized LOC105373152

Genomic regions, transcripts, and products

Phenotypes

Associated conditions

Description Tests
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46244

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
DDB1- and CUL4-associated factor 8-like protein 1
Names
WD repeat domain 42B
WD repeat-containing protein 42B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021357.1 RefSeqGene

    Range
    5001..8458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001017930.2NP_001017930.1  DDB1- and CUL4-associated factor 8-like protein 1

    See identical proteins and their annotated locations for NP_001017930.1

    Status: REVIEWED

    Source sequence(s)
    AC004553, AK128123
    Consensus CDS
    CCDS35222.1
    UniProtKB/Swiss-Prot
    A6NGE4
    Related
    ENSP00000405222.1, ENST00000441525.4
    Conserved Domains (3) summary
    COG2319
    Location:189508
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:199237
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:192508
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    27977992..27981449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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