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HDX highly divergent homeobox [ Homo sapiens (human) ]

Gene ID: 139324, updated on 23-Nov-2021

Summary

Official Symbol
HDXprovided by HGNC
Official Full Name
highly divergent homeoboxprovided by HGNC
Primary source
HGNC:HGNC:26411
See related
Ensembl:ENSG00000165259 MIM:300994
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CXorf43; D030011N01Rik
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See HDX in Genome Data Viewer
Location:
Xq21.1
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (84317878..84502578, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (83572886..83757461, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A6 Neighboring gene microRNA 548i-4 Neighboring gene testis expressed 16, pseudogene Neighboring gene SET pseudogene 4 Neighboring gene ubiquitin conjugating enzyme E2 D N-terminal like (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ30678, MGC126769, MGC126771

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017158.2 RefSeqGene

    Range
    5027..189602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177478.2NP_001170949.1  highly divergent homeobox isoform 2

    See identical proteins and their annotated locations for NP_001170949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK055240, AL035552
    Consensus CDS
    CCDS55456.1
    UniProtKB/Swiss-Prot
    Q7Z353
    Related
    ENSP00000423670.2, ENST00000506585.6
    Conserved Domains (1) summary
    cd00086
    Location:381437
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. NM_001177479.2NP_001170950.1  highly divergent homeobox isoform 1

    See identical proteins and their annotated locations for NP_001170950.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL022160, AL035552, BC143522, DA719263
    Consensus CDS
    CCDS35342.1
    UniProtKB/Swiss-Prot
    Q7Z353
    Related
    ENSP00000362272.2, ENST00000373177.3
    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:439495
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. NM_144657.5NP_653258.2  highly divergent homeobox isoform 1

    See identical proteins and their annotated locations for NP_653258.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL035552, BC101720, DA719263
    Consensus CDS
    CCDS35342.1
    UniProtKB/Swiss-Prot
    Q7Z353
    Related
    ENSP00000297977.5, ENST00000297977.9
    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:439495
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    84317878..84502578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530863.2XP_011529165.1  highly divergent homeobox isoform X1

    See identical proteins and their annotated locations for XP_011529165.1

    UniProtKB/Swiss-Prot
    Q7Z353
    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:439495
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  2. XM_006724619.1XP_006724682.1  highly divergent homeobox isoform X3

    See identical proteins and their annotated locations for XP_006724682.1

    UniProtKB/Swiss-Prot
    Q7Z353
    Conserved Domains (1) summary
    cd00086
    Location:381437
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  3. XM_017029275.1XP_016884764.1  highly divergent homeobox isoform X2

    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:421477
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  4. XM_017029274.1XP_016884763.1  highly divergent homeobox isoform X1

    UniProtKB/Swiss-Prot
    Q7Z353
    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:439495
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  5. XM_011530864.1XP_011529166.1  highly divergent homeobox isoform X1

    See identical proteins and their annotated locations for XP_011529166.1

    UniProtKB/Swiss-Prot
    Q7Z353
    Conserved Domains (2) summary
    smart00389
    Location:459
    HOX; Homeodomain
    cd00086
    Location:439495
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
  6. XM_024452336.1XP_024308104.1  highly divergent homeobox isoform X4

    Conserved Domains (1) summary
    smart00389
    Location:459
    HOX; Homeodomain

RNA

  1. XR_001755654.1 RNA Sequence

  2. XR_001755653.1 RNA Sequence

  3. XR_001755652.1 RNA Sequence

  4. XR_001755651.1 RNA Sequence

  5. XR_938392.1 RNA Sequence

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