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CRHBP corticotropin releasing hormone binding protein [ Homo sapiens (human) ]

Gene ID: 1393, updated on 6-May-2021

Summary

Official Symbol
CRHBPprovided by HGNC
Official Full Name
corticotropin releasing hormone binding proteinprovided by HGNC
Primary source
HGNC:HGNC:2356
See related
Ensembl:ENSG00000145708 MIM:122559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRFBP; CRF-BP
Summary
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]
Expression
Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues See more
Orthologs
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Genomic context

See CRHBP in Genome Data Viewer
Location:
5q13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (76952855..76981143)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (76248870..76265296)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 208, pseudogene Neighboring gene S100 calcium binding protein Z Neighboring gene RNA, U6atac small nuclear 36, pseudogene Neighboring gene angiogenic factor with G-patch and FHA domains 1 Neighboring gene zinc finger BED-type containing 3 Neighboring gene small nucleolar RNA, H/ACA box 47

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables corticotropin-releasing hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables corticotropin-releasing hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables corticotropin-releasing hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to cocaine ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to drug ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estrogen stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to gonadotropin-releasing hormone ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to potassium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female pregnancy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in female pregnancy IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hormone-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in learning or memory TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of corticotropin secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of corticotropin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of corticotropin-releasing hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of corticotropin-releasing hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulated exocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of NMDA receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cellular response to stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of corticotropin secretion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic transmission, dopaminergic ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
NOT located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon terminus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dense core granule ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in multivesicular body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perikaryon ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secondary lysosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in varicosity ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
corticotropin-releasing factor-binding protein
Names
CRF-binding protein
CRH-BP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001882.4NP_001873.2  corticotropin-releasing factor-binding protein precursor

    See identical proteins and their annotated locations for NP_001873.2

    Status: REVIEWED

    Source sequence(s)
    AW451896, BC018038, CB959505
    Consensus CDS
    CCDS4034.1
    UniProtKB/Swiss-Prot
    P24387
    Related
    ENSP00000274368.4, ENST00000274368.9
    Conserved Domains (1) summary
    pfam05428
    Location:10307
    CRF-BP; Corticotropin-releasing factor binding protein (CRF-BP)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    76952855..76981143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_948235.3 RNA Sequence

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