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Amz2 archaelysin family metallopeptidase 2 [ Mus musculus (house mouse) ]

Gene ID: 13929, updated on 18-Feb-2023

Summary

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Official Symbol
Amz2provided by MGI
Official Full Name
archaelysin family metallopeptidase 2provided by MGI
Primary source
MGI:MGI:104837
See related
Ensembl:ENSMUSG00000020610 AllianceGenome:MGI:104837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM12
Summary
Predicted to enable metal ion binding activity and metallopeptidase activity. Predicted to act upstream of or within proteolysis. Is expressed in several structures, including central nervous system; heart ventricle; and sensory organ. Orthologous to human AMZ2 (archaelysin family metallopeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 71.6), CNS E18 (RPKM 55.8) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Amz2 in Genome Data Viewer
Location:
11 E1; 11 71.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (109316772..109328974)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (109425946..109438148)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700096J18 gene Neighboring gene predicted gene 11696 Neighboring gene guanine nucleotide binding protein, alpha 13 Neighboring gene predicted gene, 45916 Neighboring gene solute carrier family 16 (monocarboxylic acid transporters), member 6 Neighboring gene arylsulfatase G Neighboring gene predicted gene, 22378

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional analysis of candidate genes from genome-wide association studies of hearing. Ingham NJ, et al. Hear Res, 2020 Mar 1. PMID 31927188, Free PMC Article
  2. Genetic mapping of 20 novel expressed sequence tags from midgestation mouse embryos suggests chromosomal clustering. Tchernev VT, et al. Genomics, 1997 Feb 15. PMID 9070936
  3. Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Bettenhausen B, et al. Genomics, 1995 Aug 10. PMID 7490078
  4. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  5. Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives. Tamplin OJ, et al. BMC Genomics, 2008 Oct 30. PMID 18973680, Free PMC Article

See all (21) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
archaemetzincin-2
Names
archeobacterial metalloproteinase-like protein 2
NP_001239122.1
NP_079551.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252193.1 → NP_001239122.1  archaemetzincin-2

    See identical proteins and their annotated locations for NP_001239122.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK075748, AL645791, CA575133
    Consensus CDS
    CCDS25579.1
    UniProtKB/Swiss-Prot
    Q400C8
    UniProtKB/TrEMBL
    A0A8C6HKH5, B1AT59
    Related
    ENSMUSP00000159063.2, ENSMUST00000238825.2
    Conserved Domains (1) summary
    cd11375
    Location:92 → 302
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

  2. NM_025275.4 → NP_079551.3  archaemetzincin-2

    See identical proteins and their annotated locations for NP_079551.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AL645791
    Consensus CDS
    CCDS25579.1
    UniProtKB/Swiss-Prot
    Q400C8
    UniProtKB/TrEMBL
    A0A8C6HKH5, B1AT59
    Related
    ENSMUSP00000090157.5, ENSMUST00000092500.11
    Conserved Domains (1) summary
    cd11375
    Location:92 → 302
    Peptidase_M54; Peptidase family M54, also called archaemetzincins or archaelysins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    109316772..109328974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q400C8.1 GenPept UniProtKB/Swiss-Prot:Q400C8

Gene LinkOut

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