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DCAF12L1 DDB1 and CUL4 associated factor 12 like 1 [ Homo sapiens (human) ]

Gene ID: 139170, updated on 9-Jun-2025
Official Symbol
DCAF12L1provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 12 like 1provided by HGNC
Primary source
HGNC:HGNC:29395
See related
Ensembl:ENSG00000198889 AllianceGenome:HGNC:29395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR40B; KIAA1892L
Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 5.0), gall bladder (RPKM 0.9) and 3 other tissues See more
Orthologs
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See DCAF12L1 in Genome Data Viewer
Location:
Xq25
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (126549383..126552814, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (124862123..124865554, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (125683366..125686797, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene MT-ND4 pseudogene 24 Neighboring gene olfactory receptor family 4 subfamily W member 1 pseudogene Neighboring gene MT-CYB pseudogene 38 Neighboring gene proline rich 32

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
DDB1- and CUL4-associated factor 12-like protein 1
Names
WD repeat domain 40B
WD repeat-containing protein 40B

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012689.1 RefSeqGene

    Range
    5046..8477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178470.5NP_848565.2  DDB1- and CUL4-associated factor 12-like protein 1

    See identical proteins and their annotated locations for NP_848565.2

    Status: REVIEWED

    Source sequence(s)
    AI139786, BC035674, BM563914, DN999337
    Consensus CDS
    CCDS14610.1
    UniProtKB/Swiss-Prot
    Q5VU92, Q8IYK3
    Related
    ENSP00000360167.1, ENST00000371126.3
    Conserved Domains (3) summary
    COG2319
    Location:152417
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:100145
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:89227
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    126549383..126552814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    124862123..124865554 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)