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MAGEC3 MAGE family member C3 [ Homo sapiens (human) ]

Gene ID: 139081, updated on 6-Sep-2022

Summary

Official Symbol
MAGEC3provided by HGNC
Official Full Name
MAGE family member C3provided by HGNC
Primary source
HGNC:HGNC:23798
See related
Ensembl:ENSG00000165509 MIM:300469; AllianceGenome:HGNC:23798
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCA2; CT7.2; MAGEC4; MAGE-C3
Summary
This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See MAGEC3 in Genome Data Viewer
Location:
Xq27.2
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (141838316..141897832)
110 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (140147128..140206644)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (140926102..140985618)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene SPANXA2 overlapping transcript 1 Neighboring gene uncharacterized LOC645188 Neighboring gene SPANX family member D Neighboring gene MAGE family member C1 Neighboring gene MAGE family member A10 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119270, MGC119271

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
melanoma-associated antigen C3
Names
MAGE family testis and tumor-specific protein
MAGE-C3 antigen
cancer/testis antigen 7.2
cancer/testis antigen family 7, member 2
hepatocellular carcinoma-associated antigen 2
hepatocellular carcinoma-associated protein HCA2
melanoma antigen family C, 3
melanoma antigen family C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013272.1 RefSeqGene

    Range
    5001..64517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_138702.1NP_619647.1  melanoma-associated antigen C3 isoform 1

    See identical proteins and their annotated locations for NP_619647.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF490508
    Consensus CDS
    CCDS14676.1
    UniProtKB/Swiss-Prot
    Q8TD91, Q9BZ80
    Related
    ENSP00000298296.1, ENST00000298296.1
  2. NM_177456.2NP_803251.1  melanoma-associated antigen C3 isoform 2

    See identical proteins and their annotated locations for NP_803251.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has several alternate splice sites, as compared to variant 1. It encodes the shorter isoform (2), which has different N- and C-termini, as compared to isoform 1.
    Source sequence(s)
    AL022152
    Consensus CDS
    CCDS14677.1
    UniProtKB/Swiss-Prot
    Q8TD91
    Related
    ENSP00000440444.1, ENST00000544766.5
    Conserved Domains (1) summary
    pfam01454
    Location:165333
    MAGE; MAGE family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    141838316..141897832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531267.4XP_011529569.1  melanoma-associated antigen C3 isoform X1

    See identical proteins and their annotated locations for XP_011529569.1

    UniProtKB/Swiss-Prot
    Q8TD91
    Related
    ENSP00000386566.1, ENST00000409007.1
    Conserved Domains (1) summary
    pfam01454
    Location:165333
    MAGE; MAGE family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    140147128..140206644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)