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Ces1e carboxylesterase 1E [ Mus musculus (house mouse) ]

Gene ID: 13897, updated on 5-Jan-2023

Summary

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Official Symbol
Ces1eprovided by MGI
Official Full Name
carboxylesterase 1Eprovided by MGI
Primary source
MGI:MGI:95432
See related
Ensembl:ENSMUSG00000061959 AllianceGenome:MGI:95432
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eg; Es22; Es-22; egasyn
Summary
Enables carboxylic ester hydrolase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in several structures, including alimentary system; hemolymphoid system; liver; nose; and respiratory system. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver adult (RPKM 36.8), kidney adult (RPKM 21.8) and 3 other tissues See more
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Genomic context

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See Ces1e in Genome Data Viewer
Location:
8 C5; 8 45.11 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93927846..93956259, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93201218..93229631, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 45910 Neighboring gene carboxylesterase 1D Neighboring gene carboxylesterase 1F Neighboring gene carboxylesterase 1G

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and androgen regulation of egasyn in the mouse epididymis. Abou-Haila A, et al. Biochim Biophys Acta, 1998 Feb 4. PMID 9531973
  2. Separate genes determining the structure and intracellular location of hepatic glucuronidase. Ganschow R, et al. Proc Natl Acad Sci U S A, 1967 Sep. PMID 5233850, Free PMC Article
  3. The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver. Swank RT, et al. Biochem J, 1986 Dec 1. PMID 3101673, Free PMC Article
  4. Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues. Lusis AJ, et al. J Cell Biol, 1977 Jun. PMID 873997, Free PMC Article
  5. Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels. Lusis AJ, et al. Biochem Genet, 1977 Feb. PMID 849245

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the carboxylesterase 1d (Ces1d) and carboxylesterase 1e (Ces1e) expression and the capacity of hydrolytic activity of liver and intestine decreased, whereas the Akt/mTOR/HIF-1alpha/ Stra13 (DEC1) signaling was activated in type 2 diabetes mice.
    Title: Decreased carboxylesterases expression and hydrolytic activity in type 2 diabetic mice through Akt/mTOR/HIF-1α/Stra13 pathway.
  2. The Es22 plays a role in liver retinoid metabolism.
    Title: Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-CoA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables retinyl-palmitate esterase activity ISO
Inferred from Sequence Orthology
more info
  
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carboxylesterase 1E
Names
esterase-22
liver carboxylesterase 22
NP_598421.1
XP_006530714.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001403733.1 → NP_001390662.1  carboxylesterase 1E isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC162949
    UniProtKB/TrEMBL
    H3BL34

  2. NM_133660.4 → NP_598421.1  carboxylesterase 1E isoform 1 precursor

    See identical proteins and their annotated locations for NP_598421.1

    Status: VALIDATED

    Source sequence(s)
    AC162949
    Consensus CDS
    CCDS22529.1
    UniProtKB/Swiss-Prot
    Q64176
    UniProtKB/TrEMBL
    Q3UN14
    Related
    ENSMUSP00000034173.8, ENSMUST00000034173.14
    Conserved Domains (2) summary
    COG0657
    Location:44 → 242
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:25 → 546
    COesterase; Carboxylesterase family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93927846..93956259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530651.3 → XP_006530714.1  carboxylesterase 1E isoform X1

    UniProtKB/TrEMBL
    H3BL34
    Related
    ENSMUSP00000135636.2, ENSMUST00000176282.2
    Conserved Domains (1) summary
    pfam00135
    Location:24 → 545
    COesterase; Carboxylesterase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q64176.1 GenPept UniProtKB/Swiss-Prot:Q64176

Gene LinkOut

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