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Ces1c carboxylesterase 1C [ Mus musculus (house mouse) ]

Gene ID: 13884, updated on 24-Jan-2023

Summary

Official Symbol
Ces1cprovided by MGI
Official Full Name
carboxylesterase 1Cprovided by MGI
Primary source
MGI:MGI:95420
See related
Ensembl:ENSMUSG00000057400 AllianceGenome:MGI:95420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ee1; Es1; Es4; EsN; Ee-1; Es-4; Es-N; PESN; Ces-N
Summary
Enables carboxylic ester hydrolase activity. Acts upstream of or within response to bacterium. Located in extracellular space. Is expressed in several structures, including alimentary system; liver; nose; respiratory system; and urinary system. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward liver adult (RPKM 843.5) See more
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Genomic context

See Ces1c in Genome Data Viewer
Location:
8 C5; 8 44.99 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93825643..93857911, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93099015..93131283, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene carboxylesterase 1A Neighboring gene carboxylesterase 1B Neighboring gene predicted gene 45910 Neighboring gene carboxylesterase 1D

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (3) 

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxylesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxylesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables carboxylic ester hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on ester bonds IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity, acting on ester bonds IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables sterol esterase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to low-density lipoprotein particle stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in medium-chain fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cholesterol storage ISO
Inferred from Sequence Orthology
more info
 
involved_in organic substance catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in organic substance catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bile acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in reverse cholesterol transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carboxylesterase 1C
Names
PES-N
esterase 1
liver carboxylesterase N
lung surfactant convertase
NP_031980.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007954.4NP_031980.2  carboxylesterase 1C precursor

    See identical proteins and their annotated locations for NP_031980.2

    Status: VALIDATED

    Source sequence(s)
    AA286207, AC121985, AI047526, AI116924, AI527022
    Consensus CDS
    CCDS22527.1
    UniProtKB/Swiss-Prot
    P23953, Q8K125
    Related
    ENSMUSP00000034189.9, ENSMUST00000034189.17
    Conserved Domains (2) summary
    COG0657
    Location:121234
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    cd00312
    Location:25525
    Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    93825643..93857911 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)