Erf Ets2 repressor factor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erfprovided by MGI
Official Full Name: Ets2 repressor factorprovided by MGI
Primary source: MGI:MGI:109637
See related: Ensembl:ENSMUSG00000040857 AllianceGenome:MGI:109637
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Acts upstream of or within chorio-allantoic fusion; ectodermal cell differentiation; and trophoblast giant cell differentiation. Located in nucleus. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and nervous system. Human ortholog(s) of this gene implicated in craniosynostosis. Orthologous to human ERF (ETS2 repressor factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in limb E14.5 (RPKM 38.0), ovary adult (RPKM 27.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 13.73 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (24941985..24950529, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25242560..25251104, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment.
Title: ETS2 repressor factor (ERF) is involved in T lymphocyte maturation acting as regulator of thymocyte lineage commitment.
deletion of Erf rescues the proliferative defects of RAS-devoid embryonic stem cells and restores their capacity to differentiate.
Title: ERF deletion rescues RAS deficiency in mouse embryonic stem cells.
data provide evidence that the oncogenicity of ERG is mediated, in part, by competition with ERF and they raise the larger question of whether other gain-of-function oncogenic transcription factors might also inactivate endogenous tumour suppressors
Title: ERF mutations reveal a balance of ETS factors controlling prostate oncogenesis.
Results provide evidence that Erf is required for both primitive and erythromyeloid progenitor waves of hematopoietic stem cell (HSC)-independent hematopoiesis as well as for the normal function of HSCs.
Title: The Ets2 Repressor Factor (Erf) Is Required for Effective Primitive and Definitive Hematopoiesis.
Oncogenic Ras may play a role in epithelial mesenchymal transition via the ERF and regulation of Semaphorin-7a.
Title: Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells.
Erf provides a direct link between the RAS/ERK signaling and the transcriptional regulation of c-Myc and suggests that RAS/ERK attenuation actively regulates cell fate
Title: The RAS-dependent ERF control of cell proliferation and differentiation is mediated by c-Myc repression.
These studies suggest "repressing repressors" as a potential strategy for achieving utrophin up-regulation in Duchenne's muscular dystrophy, and they provide a model for utrophin-A regulation in muscle.
Title: Ets-2 repressor factor silences extrasynaptic utrophin by N-box mediated repression in skeletal muscle.
These data suggest that attenuation of FGF/Erk signaling and consecutive Erf nuclear localization and function is required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment.
Title: Transcriptional repressor erf determines extraembryonic ectoderm differentiation.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Erf gene: The Erf gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, zebrafish, and frog.
Orthologs from Annotation Pipeline: 239 organisms have orthologs with human gene Erf
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription repressor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within chorio-allantoic fusion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectodermal cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within trophoblast giant cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ETS domain-containing transcription factor ERF

Names: Est2 repressor factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412415.1 → NP_001399344.1 ETS domain-containing transcription factor ERF isoform a

Status: VALIDATED

Source sequence(s)

AC156992
NM_001412417.1 → NP_001399346.1 ETS domain-containing transcription factor ERF isoform c

Status: VALIDATED

Source sequence(s)

AC156992
NM_001412418.1 → NP_001399347.1 ETS domain-containing transcription factor ERF isoform c

Status: VALIDATED

Source sequence(s)

AC156992
NM_010155.4 → NP_034285.3 ETS domain-containing transcription factor ERF isoform b

See identical proteins and their annotated locations for NP_034285.3

Status: VALIDATED

Source sequence(s)

AC156992

Consensus CDS

CCDS20978.1

UniProtKB/Swiss-Prot

P70459

UniProtKB/TrEMBL

A0A0R4J0I0

Related

ENSMUSP00000041912.9, ENSMUST00000045847.15

Conserved Domains (1) summary

smart00413
Location:26 → 111

ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

24941985..24950529 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030242129.1 → XP_030097989.1 ETS domain-containing transcription factor ERF isoform X2

Conserved Domains (2) summary

PHA03247
Location:51 → 308

PHA03247; large tegument protein UL36; Provisional

cl02599
Location:1 → 36

Ets; Ets-domain
XM_030242130.2 → XP_030097990.1 ETS domain-containing transcription factor ERF isoform X2

Conserved Domains (2) summary

PHA03247
Location:51 → 308

PHA03247; large tegument protein UL36; Provisional

cl02599
Location:1 → 36

Ets; Ets-domain
XM_030242128.2 → XP_030097988.1 ETS domain-containing transcription factor ERF isoform X1

Conserved Domains (2) summary

smart00413
Location:27 → 112

ETS; erythroblast transformation specific domain

PHA03247
Location:127 → 384

PHA03247; large tegument protein UL36; Provisional