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RPP25L ribonuclease P/MRP subunit p25 like [ Homo sapiens (human) ]

Gene ID: 138716, updated on 4-Oct-2020

Summary

Official Symbol
RPP25Lprovided by HGNC
Official Full Name
ribonuclease P/MRP subunit p25 likeprovided by HGNC
Primary source
HGNC:HGNC:19909
See related
Ensembl:ENSG00000164967
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C9orf23; bA296L22.5
Summary
This gene encodes a protein that appears to belong to a family of evolutionarily related proteins (DUF78), that may share one or more domains in common. Members of this family are small archaebacterial proteins with no known function. Alternative splicing has been observed at this locus and two variants, both encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 9.6), prostate (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See RPP25L in Genome Data Viewer
Location:
9p13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (34610495..34612097, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34610482..34612110, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene energy homeostasis associated Neighboring gene ciliary neurotrophic factor receptor Neighboring gene uncharacterized LOC105376023 Neighboring gene CNTFR antisense RNA 1 Neighboring gene dynactin subunit 3 Neighboring gene AT-rich interaction domain 3C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC29635

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonuclease MRP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ribonuclease P protein subunit p25-like protein
Names
RNase P protein subunit-like p25
alba-like protein C9orf23
ribonuclease P/MRP 25kDa subunit-like
rpp25-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148178.3NP_680544.1  ribonuclease P protein subunit p25-like protein

    See identical proteins and their annotated locations for NP_680544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL528391, BC032136
    Consensus CDS
    CCDS6559.1
    UniProtKB/Swiss-Prot
    Q8N5L8
    Related
    ENSP00000368242.4, ENST00000378959.9
    Conserved Domains (1) summary
    pfam01918
    Location:2789
    Alba
  2. NM_148179.3NP_680545.1  ribonuclease P protein subunit p25-like protein

    See identical proteins and their annotated locations for NP_680545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI016726, AL528391, DT218980
    Consensus CDS
    CCDS6559.1
    UniProtKB/Swiss-Prot
    Q8N5L8
    Related
    ENSP00000297613.4, ENST00000297613.4
    Conserved Domains (1) summary
    pfam01918
    Location:2789
    Alba

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    34610495..34612097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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