Format

Send to:

Choose Destination

PTPDC1 protein tyrosine phosphatase domain containing 1 [ Homo sapiens (human) ]

Gene ID: 138639, updated on 23-Nov-2021

Summary

Official Symbol
PTPDC1provided by HGNC
Official Full Name
protein tyrosine phosphatase domain containing 1provided by HGNC
Primary source
HGNC:HGNC:30184
See related
Ensembl:ENSG00000158079
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTP9Q22
Summary
The protein encoded by this gene contains a characteristic motif of protein tyrosine phosphatases (PTPs). PTPs regulate activities of phosphoproteins through dephosphorylation. They are signaling molecules involved in the regulation of a wide variety of biological processes. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 3.6), adrenal (RPKM 2.2) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PTPDC1 in Genome Data Viewer
Location:
9q22.32
Exon count:
15
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (94029031..94109856)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (96793095..96872138)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene BARX1 divergent transcript Neighboring gene BARX homeobox 1 Neighboring gene CYCS pseudogene 24 Neighboring gene tripartite motif-containing protein 54-like Neighboring gene PTPDC1-MIRLET7DHG intergenic CAGE-defined high expression enhancer Neighboring gene miRlet-7a-1/let-7f-1/let-7d cluster host gene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.
GeneReviews: Not available
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ42922

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
protein tyrosine phosphatase domain-containing protein 1
Names
protein tyrosine phosphatase PTP9Q22
NP_001240758.1
NP_001240759.1
NP_689635.3
NP_818931.1
XP_005251768.1
XP_011516542.1
XP_011516543.1
XP_016869769.1
XP_016869770.1
XP_016869771.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253829.2NP_001240758.1  protein tyrosine phosphatase domain-containing protein 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AK289692, AW052114, BC067120, DA218576, DA312531
    Consensus CDS
    CCDS75860.1
    UniProtKB/Swiss-Prot
    A2A3K4
    UniProtKB/TrEMBL
    A0A087WTF0, A8K0X7
    Related
    ENSP00000477817.1, ENST00000620992.5
    Conserved Domains (1) summary
    smart00404
    Location:208289
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  2. NM_001253830.2NP_001240759.1  protein tyrosine phosphatase domain-containing protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001240759.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094631, AW052114, BC051654, BC067120
    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  3. NM_152422.4NP_689635.3  protein tyrosine phosphatase domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_689635.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform (1).
    Source sequence(s)
    AK094631, AK124912, AW052114, BC031279, BC067120, DA218576
    Consensus CDS
    CCDS6708.1
    UniProtKB/Swiss-Prot
    A2A3K4
    Related
    ENSP00000288976.3, ENST00000288976.3
    Conserved Domains (1) summary
    smart00404
    Location:206287
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  4. NM_177995.3NP_818931.1  protein tyrosine phosphatase domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_818931.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK094631, AW052114, BC067120
    Consensus CDS
    CCDS6707.1
    UniProtKB/Swiss-Prot
    A2A3K4
    Related
    ENSP00000364509.3, ENST00000375360.7
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    94029031..94109856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014282.2XP_016869771.1  protein tyrosine phosphatase domain-containing protein 1 isoform X2

    Conserved Domains (1) summary
    smart00404
    Location:26111
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  2. XM_017014281.2XP_016869770.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  3. XM_005251711.5XP_005251768.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005251768.1

    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  4. XM_011518240.3XP_011516542.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516542.1

    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  5. XM_017014280.2XP_016869769.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
  6. XM_011518241.3XP_011516543.1  protein tyrosine phosphatase domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011516543.1

    UniProtKB/Swiss-Prot
    A2A3K4
    Conserved Domains (1) summary
    smart00404
    Location:154235
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
Support Center