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Epo erythropoietin [ Mus musculus (house mouse) ]

Gene ID: 13856, updated on 16-Dec-2019

Summary

Official Symbol
Epoprovided by MGI
Official Full Name
erythropoietinprovided by MGI
Primary source
MGI:MGI:95407
See related
Ensembl:ENSMUSG00000029711
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes the glycoprotein hormone erythropoietin that regulates the production of red blood cells and biosynthesis of hemoglobin. The predominant expression of this gene shifts from the liver during fetal development to kidney in adults. A complete lack of the encoded protein causes embryonic lethal anemia in mice. The conditional inactivation of this gene in adult mice results in a chronic, normocytic and normochromic anemia. Transgenic mice expressing the human ortholog of this gene exhibit polycythemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See Epo in Genome Data Viewer
Location:
5 G2; 5 76.5 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137483020..137485816, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (137924248..137927044, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene zonadhesin Neighboring gene ribosomal protein L36, pseudogene 9 Neighboring gene predicted gene, 38725 Neighboring gene predicted gene, 36056 Neighboring gene processing of precursor 7, ribonuclease P family, (S. cerevisiae) Neighboring gene GRB10 interacting GYF protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine activity ISO
Inferred from Sequence Orthology
more info
 
erythropoietin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
erythropoietin receptor binding ISO
Inferred from Sequence Orthology
more info
 
erythropoietin receptor binding TAS
Traceable Author Statement
more info
PubMed 
hormone activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
angiogenesis TAS
Traceable Author Statement
more info
PubMed 
apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
cardiac muscle tissue morphogenesis TAS
Traceable Author Statement
more info
PubMed 
cell proliferation ISO
Inferred from Sequence Orthology
more info
 
cellular hyperosmotic response ISO
Inferred from Sequence Orthology
more info
 
embryo implantation IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
erythrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
 
erythropoietin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
erythropoietin-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis TAS
Traceable Author Statement
more info
PubMed 
hemoglobin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemoglobin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of calcium ion transport into cytosol ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cation channel activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of erythrocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myeloid cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of tyrosine phosphorylation of STAT protein ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
response to hypoxia IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
vasculogenesis involved in coronary vascular morphogenesis TAS
Traceable Author Statement
more info
PubMed 
ventricular cardiac muscle tissue morphogenesis TAS
Traceable Author Statement
more info
PubMed 
visceral serous pericardium development TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cell body ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001312875.1NP_001299804.1  erythropoietin isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    BC119265
    Consensus CDS
    CCDS84978.1
    UniProtKB/TrEMBL
    B7ZMY9, Q0VED9
    Related
    ENSMUSP00000106668.1, ENSMUST00000111039.2
    Conserved Domains (1) summary
    pfam00758
    Location:30190
    EPO_TPO; Erythropoietin/thrombopoietin
  2. NM_007942.2NP_031968.1  erythropoietin isoform 1 precursor

    See identical proteins and their annotated locations for NP_031968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    BC119265
    Consensus CDS
    CCDS39332.1
    UniProtKB/Swiss-Prot
    P07321
    UniProtKB/TrEMBL
    Q0VED9
    Related
    ENSMUSP00000031723.6, ENSMUST00000031723.13
    Conserved Domains (1) summary
    pfam00758
    Location:30191
    EPO_TPO; Erythropoietin/thrombopoietin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p6 C57BL/6J

    Range
    137483020..137485816 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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