U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epn2 epsin 2 [ Mus musculus (house mouse) ]

Gene ID: 13855, updated on 9-May-2024

Summary

Official Symbol
Epn2provided by MGI
Official Full Name
epsin 2provided by MGI
Primary source
MGI:MGI:1333766
See related
Ensembl:ENSMUSG00000001036 AllianceGenome:MGI:1333766
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibp2; 9530051D10Rik
Summary
Predicted to enable clathrin binding activity and phospholipid binding activity. Acts upstream of or within Notch signaling pathway; embryonic organ development; and in utero embryonic development. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of clathrin coat of endocytic vesicle. Predicted to be active in endosome and plasma membrane. Orthologous to human EPN2 (epsin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 26.3), cerebellum adult (RPKM 19.7) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Epn2 in Genome Data Viewer
Location:
11 B2; 11 37.96 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61406709..61470560, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61515883..61579717, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6995 Neighboring gene mitogen-activated protein kinase 7 Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene STARR-seq mESC enhancer starr_29682 Neighboring gene STARR-positive B cell enhancer ABC_E3957 Neighboring gene STARR-positive B cell enhancer ABC_E3958 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:61483303-61483412 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of clathrin coat of endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
epsin-2
Names
EPS-15-interacting protein 2
intersectin-EH-binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252188.2NP_001239117.1  epsin-2 isoform 1

    See identical proteins and their annotated locations for NP_001239117.1

    Status: VALIDATED

    Source sequence(s)
    AK139234, AK160782, AL604029
    Consensus CDS
    CCDS56780.1
    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Related
    ENSMUSP00000136950.2, ENSMUST00000179936.8
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  2. NM_001252189.2NP_001239118.1  epsin-2 isoform 3

    See identical proteins and their annotated locations for NP_001239118.1

    Status: VALIDATED

    Source sequence(s)
    AK160782, AL604029
    Consensus CDS
    CCDS56779.1
    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Related
    ENSMUSP00000104353.2, ENSMUST00000108713.8
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  3. NM_001362585.1NP_001349514.1  epsin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL604029
    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  4. NM_001362586.1NP_001349515.1  epsin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL604029
    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  5. NM_001362587.1NP_001349516.1  epsin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Consensus CDS
    CCDS24816.1
    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  6. NM_010148.4NP_034278.1  epsin-2 isoform 2

    See identical proteins and their annotated locations for NP_034278.1

    Status: VALIDATED

    Source sequence(s)
    AK160782, AL604029, CX123717
    Consensus CDS
    CCDS24816.1
    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Related
    ENSMUSP00000001063.9, ENSMUST00000001063.15
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    61406709..61470560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532165.5XP_006532228.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532228.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  2. XM_036156313.1XP_036012206.1  epsin-2 isoform X6

  3. XM_036156312.1XP_036012205.1  epsin-2 isoform X5

  4. XM_030245537.2XP_030101397.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  5. XM_030245533.2XP_030101393.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Related
    ENSMUSP00000136553.2, ENSMUST00000178202.8
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  6. XM_006532171.5XP_006532234.1  epsin-2 isoform X2

    See identical proteins and their annotated locations for XP_006532234.1

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Related
    ENSMUSP00000104352.2, ENSMUST00000108712.8
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  7. XM_030245539.2XP_030101399.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  8. XM_036156302.1XP_036012195.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  9. XM_030245538.2XP_030101398.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  10. XM_006532166.5XP_006532229.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532229.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  11. XM_006532168.5XP_006532231.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532231.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  12. XM_036156307.1XP_036012200.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  13. XM_030245531.2XP_030101391.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  14. XM_030245528.2XP_030101388.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  15. XM_011248711.4XP_011247013.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_011247013.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  16. XM_036156305.1XP_036012198.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  17. XM_036156303.1XP_036012196.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  18. XM_006532167.5XP_006532230.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532230.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  19. XM_036156308.1XP_036012201.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  20. XM_036156296.1XP_036012189.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  21. XM_036156292.1XP_036012185.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  22. XM_036156306.1XP_036012199.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  23. XM_036156299.1XP_036012192.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  24. XM_036156291.1XP_036012184.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  25. XM_036156309.1XP_036012202.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Related
    ENSMUSP00000104351.2, ENSMUST00000108711.8
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  26. XM_030245534.2XP_030101394.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  27. XM_036156301.1XP_036012194.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  28. XM_006532170.5XP_006532233.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532233.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  29. XM_036156297.1XP_036012190.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  30. XM_036156311.1XP_036012204.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  31. XM_036156300.1XP_036012193.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  32. XM_036156295.1XP_036012188.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  33. XM_036156310.1XP_036012203.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  34. XM_036156293.1XP_036012186.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  35. XM_030245540.2XP_030101400.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  36. XM_030245535.2XP_030101395.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  37. XM_006532169.5XP_006532232.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532232.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  38. XM_036156294.1XP_036012187.1  epsin-2 isoform X1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  39. XM_036156304.1XP_036012197.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  40. XM_030245530.2XP_030101390.1  epsin-2 isoform X2

    UniProtKB/TrEMBL
    J3QNT7, Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  41. XM_011248713.4XP_011247015.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_011247015.1

    UniProtKB/TrEMBL
    Q5NCM5
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  42. XM_030245541.2XP_030101401.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  43. XM_030245532.2XP_030101392.1  epsin-2 isoform X3

    UniProtKB/Swiss-Prot
    O70447, Q5NCM4, Q8BZ85, Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM6
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
  44. XM_030245536.1XP_030101396.1  epsin-2 isoform X4

    UniProtKB/TrEMBL
    Q5NCM6, Q5NCM7
    Conserved Domains (1) summary
    cd16990
    Location:19141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family