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Epn2 epsin 2 [ Mus musculus (house mouse) ]

Gene ID: 13855, updated on 14-Aug-2019

Summary

Official Symbol
Epn2provided by MGI
Official Full Name
epsin 2provided by MGI
Primary source
MGI:MGI:1333766
See related
Ensembl:ENSMUSG00000001036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ibp2; AA536924; 9530051D10Rik
Expression
Ubiquitous expression in lung adult (RPKM 26.3), cerebellum adult (RPKM 19.7) and 24 other tissues See more
Orthologs

Genomic context

See Epn2 in Genome Data Viewer
Location:
11; 11 B2
Exon count:
17
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61515883..61579717, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61330751..61393153, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene B9 protein domain 1, opposite strand Neighboring gene B9 protein domain 1 Neighboring gene GRB2-related adaptor protein Neighboring gene solute carrier family 5 (sodium/glucose cotransporter), member 10 Neighboring gene family with sequence similarity 83, member G

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of vascular endothelial growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
clathrin coat of endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
epsin-2
Names
EPS-15-interacting protein 2
intersectin-EH-binding protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252188.2NP_001239117.1  epsin-2 isoform 1

    See identical proteins and their annotated locations for NP_001239117.1

    Status: VALIDATED

    Source sequence(s)
    AK139234, AK160782, AL604029
    Consensus CDS
    CCDS56780.1
    UniProtKB/TrEMBL
    J3QNT7, Q5NCM7
    Related
    ENSMUSP00000136950.1, ENSMUST00000179936.7
    Conserved Domains (1) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  2. NM_001252189.2NP_001239118.1  epsin-2 isoform 3

    See identical proteins and their annotated locations for NP_001239118.1

    Status: VALIDATED

    Source sequence(s)
    AK160782, AL604029
    Consensus CDS
    CCDS56779.1
    UniProtKB/Swiss-Prot
    Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM7
    Related
    ENSMUSP00000104353.1, ENSMUST00000108713.7
    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl00427
    Location:335399
    TM_PBP2; Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and ...
  3. NM_001362585.1NP_001349514.1  epsin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. NM_001362586.1NP_001349515.1  epsin-2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  5. NM_001362587.1NP_001349516.1  epsin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL604029
    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:291592
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  6. NM_010148.4NP_034278.1  epsin-2 isoform 2

    See identical proteins and their annotated locations for NP_034278.1

    Status: VALIDATED

    Source sequence(s)
    AK160782, AL604029, CX123717
    Consensus CDS
    CCDS24816.1
    UniProtKB/Swiss-Prot
    Q8CHU3
    UniProtKB/TrEMBL
    Q5NCM7
    Related
    ENSMUSP00000001063.8, ENSMUST00000001063.14
    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:291592
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    61515883..61579717 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532171.4XP_006532234.1  epsin-2 isoform X2

    See identical proteins and their annotated locations for XP_006532234.1

    UniProtKB/TrEMBL
    J3QNT7
    Related
    ENSMUSP00000104352.1, ENSMUST00000108712.7
    Conserved Domains (1) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
  2. XM_030245534.1XP_030101394.1  epsin-2 isoform X3

  3. XM_006532170.4XP_006532233.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532233.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. XM_030245539.1XP_030101399.1  epsin-2 isoform X4

    Related
    ENSMUSP00000104351.1, ENSMUST00000108711.7
  5. XM_030245538.1XP_030101398.1  epsin-2 isoform X4

  6. XM_006532166.4XP_006532229.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532229.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  7. XM_030245537.1XP_030101397.1  epsin-2 isoform X4

  8. XM_030245533.1XP_030101393.1  epsin-2 isoform X3

    Related
    ENSMUSP00000136553.1, ENSMUST00000178202.7
  9. XM_006532165.4XP_006532228.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532228.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  10. XM_006532168.4XP_006532231.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532231.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  11. XM_030245531.1XP_030101391.1  epsin-2 isoform X3

  12. XM_030245528.1XP_030101388.1  epsin-2 isoform X2

  13. XM_011248711.3XP_011247013.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_011247013.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  14. XM_006532167.4XP_006532230.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532230.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  15. XM_006532169.4XP_006532232.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_006532232.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  16. XM_030245535.1XP_030101395.1  epsin-2 isoform X3

  17. XM_030245540.1XP_030101400.1  epsin-2 isoform X4

  18. XM_030245529.1XP_030101389.1  epsin-2 isoform X2

  19. XM_030245536.1XP_030101396.1  epsin-2 isoform X4

  20. XM_030245530.1XP_030101390.1  epsin-2 isoform X2

  21. XM_030245541.1XP_030101401.1  epsin-2 isoform X4

  22. XM_030245532.1XP_030101392.1  epsin-2 isoform X3

  23. XM_011248713.3XP_011247015.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_011247015.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  24. XM_011248712.3XP_011247014.1  epsin-2 isoform X1

    See identical proteins and their annotated locations for XP_011247014.1

    Conserved Domains (2) summary
    cd03571
    Location:19141
    ENTH_epsin; ENTH domain, Epsin family; The epsin (Eps15 interactor) N-terminal homology (ENTH) domain is an evolutionarily conserved protein module found primarily in proteins that participate in clathrin-mediated endocytosis. A set of proteins previously designated ...
    cl25496
    Location:348649
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
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