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CREB1 cAMP responsive element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1385, updated on 20-Nov-2022

Summary

Official Symbol
CREB1provided by HGNC
Official Full Name
cAMP responsive element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2345
See related
Ensembl:ENSG00000118260 MIM:123810; AllianceGenome:HGNC:2345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREB; CREB-1
Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in lymph node (RPKM 5.0), thyroid (RPKM 4.7) and 25 other tissues See more
Orthologs
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Genomic context

See CREB1 in Genome Data Viewer
Location:
2q33.3
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (207529962..207605988)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208003958..208080006)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208394686..208470712)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373851 Neighboring gene uncharacterized LOC124907970 Neighboring gene methyltransferase 21A, HSPA lysine Neighboring gene long intergenic non-protein coding RNA 1857 Neighboring gene ribosomal protein S29 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Angiomatoid fibrous histiocytoma
MedGen: C1266127 OMIM: 612160 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
Tat tat HIV-1 Tat induces upregulation of HDAC2 expression and downregulation of CREB and CaMKIIa expression in human neuroblastoma SK-N-MC cells PubMed
tat The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1 PubMed
tat HIV-1 Tat increases both CREB phosphorylation and DNA binding by 7- to 10-fold within 2 hours after stimulation in hematopoietic progenitor cells PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription PubMed
tat HIV-1 Tat upregulates IL-10 synthesis by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation PubMed
tat HIV-1 Tat protein downregulates the Ser-133 phosphorylation, activation, and expression of CREB transcription factor in PC12 neuronal cells through sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed
tat Extracellular HIV-1 Tat protein induces the rapid Ser-133 phosphorylation and activation of CREB transcription factor in lymphoid cells through a signal cascade involving the MAPK pathway PubMed
Vpr vpr The RNA and protein levels of cAMP responsive element binding protein (CREB) decreases in Vpr-treated human neurons compared to the untreated control PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9284

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to forskolin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
involved_in circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in lactation IEA
Inferred from Electronic Annotation
more info
 
involved_in lung saccule development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in memory IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transcription by competitive promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
PubMed 
involved_in response to glucagon ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to purine-containing compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in secretory granule organization IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of ATF4-CREB1 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of RNA polymerase II transcription regulator complex IC
Inferred by Curator
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
active transcription factor CREB
cAMP-response element-binding protein-1
cyclic adenosine 3',5'-monophosphate response element binding protein
cyclic adenosine 3',5'-monophosphate response element-binding protein CREB
transactivator protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023299.1 RefSeqGene

    Range
    5071..81097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320793.2NP_001307722.1  cyclic AMP-responsive element-binding protein 1 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (C) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform B.
    Source sequence(s)
    AC009298, AK298740, DC366797
    UniProtKB/TrEMBL
    B7Z5C6
    Conserved Domains (1) summary
    pfam02173
    Location:99137
    pKID; pKID domain
  2. NM_001371426.1NP_001358355.1  cyclic AMP-responsive element-binding protein 1 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS2375.1
    UniProtKB/TrEMBL
    A0A024R401
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain
  3. NM_001371427.1NP_001358356.1  cyclic AMP-responsive element-binding protein 1 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Consensus CDS
    CCDS2374.1
    UniProtKB/Swiss-Prot
    Q9UMA7
    UniProtKB/TrEMBL
    A0A024R437
    Related
    ENSP00000405539.1, ENST00000430624.5
    Conserved Domains (2) summary
    cd14690
    Location:271325
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:99137
    pKID; pKID domain
  4. NM_001371428.1NP_001358357.1  cyclic AMP-responsive element-binding protein 1 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Related
    ENSP00000405711.1, ENST00000448277.5
    Conserved Domains (2) summary
    cd14690
    Location:231285
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5997
    pKID; pKID domain
  5. NM_004379.5NP_004370.1  cyclic AMP-responsive element-binding protein 1 isoform A

    See identical proteins and their annotated locations for NP_004370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as A) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (A) has the same N- and C-termini but is shorter compared to isoform B.
    Source sequence(s)
    AC079767, BC095407, BU154326
    Consensus CDS
    CCDS2374.1
    UniProtKB/Swiss-Prot
    P16220, Q9UMA7
    UniProtKB/TrEMBL
    A0A024R437, Q53X93
    Related
    ENSP00000236995.3, ENST00000353267.8
    Conserved Domains (2) summary
    cd14690
    Location:271325
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:99137
    pKID; pKID domain
  6. NM_134442.5NP_604391.1  cyclic AMP-responsive element-binding protein 1 isoform B

    See identical proteins and their annotated locations for NP_604391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as B) represents the longest transcript and encodes the longest isoform (B).
    Source sequence(s)
    AC079767, BC010636, BU154326, DC366797
    Consensus CDS
    CCDS2375.1
    UniProtKB/Swiss-Prot
    P16220
    UniProtKB/TrEMBL
    A0A024R401, Q5U0J5
    Related
    ENSP00000387699.2, ENST00000432329.6
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain

RNA

  1. NR_135473.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment in the 3' end compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079767, BC010636, BU154326, DC366797, HY204508
  2. NR_163946.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
  3. NR_163947.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    207529962..207605988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510646.4XP_011508948.1  cyclic AMP-responsive element-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02173
    Location:113151
    pKID; pKID domain
  2. XM_047443437.1XP_047299393.1  cyclic AMP-responsive element-binding protein 1 isoform X3

  3. XM_047443436.1XP_047299392.1  cyclic AMP-responsive element-binding protein 1 isoform X3

  4. XM_011510648.4XP_011508950.1  cyclic AMP-responsive element-binding protein 1 isoform X4

    Conserved Domains (1) summary
    pfam02173
    Location:113151
    pKID; pKID domain
  5. XM_017003399.3XP_016858888.1  cyclic AMP-responsive element-binding protein 1 isoform X6

  6. XM_047443438.1XP_047299394.1  cyclic AMP-responsive element-binding protein 1 isoform X4

  7. XM_047443440.1XP_047299396.1  cyclic AMP-responsive element-binding protein 1 isoform X7

  8. XM_047443439.1XP_047299395.1  cyclic AMP-responsive element-binding protein 1 isoform X7

  9. XM_047443441.1XP_047299397.1  cyclic AMP-responsive element-binding protein 1 isoform X8

  10. XM_047443442.1XP_047299398.1  cyclic AMP-responsive element-binding protein 1 isoform X9

    Related
    ENSP00000407227.1, ENST00000445803.5
  11. XM_047443443.1XP_047299399.1  cyclic AMP-responsive element-binding protein 1 isoform X10

  12. XM_047443435.1XP_047299391.1  cyclic AMP-responsive element-binding protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A024R401
  13. XM_011510650.4XP_011508952.1  cyclic AMP-responsive element-binding protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011508952.1

    Conserved Domains (2) summary
    cd14690
    Location:245299
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:73111
    pKID; pKID domain
  14. XM_047443444.1XP_047299400.1  cyclic AMP-responsive element-binding protein 1 isoform X11

  15. XM_017003401.3XP_016858890.1  cyclic AMP-responsive element-binding protein 1 isoform X12

    Conserved Domains (1) summary
    cd14690
    Location:55109
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    208003958..208080006
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)