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CREB1 cAMP responsive element binding protein 1 [ Homo sapiens (human) ]

Gene ID: 1385, updated on 10-Oct-2020

Summary

Official Symbol
CREB1provided by HGNC
Official Full Name
cAMP responsive element binding protein 1provided by HGNC
Primary source
HGNC:HGNC:2345
See related
Ensembl:ENSG00000118260 MIM:123810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CREB; CREB-1
Summary
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in lymph node (RPKM 5.0), thyroid (RPKM 4.7) and 25 other tissues See more
Orthologs

Genomic context

See CREB1 in Genome Data Viewer
Location:
2q33.3
Exon count:
13
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (207529943..207605988)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (208394616..208470284)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1802 Neighboring gene microRNA 1302-4 Neighboring gene uncharacterized LOC105373851 Neighboring gene methyltransferase like 21A Neighboring gene long intergenic non-protein coding RNA 1857 Neighboring gene ribosomal protein S29 pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Angiomatoid fibrous histiocytoma
MedGen: C1266127 OMIM: 612160 GeneReviews: Not available
Compare labs
Genome-wide genetic and transcriptomic investigation of variation in antibody response to dietary antigens.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuron death is inhibited by CCL3L1 treatment via the phosphorylation of CREB, the upregulation of Bcl-2, and the PKA and CaMKI/CaMKIV cell signaling pathways PubMed
Tat tat HIV-1 Tat induces upregulation of HDAC2 expression and downregulation of CREB and CaMKIIa expression in human neuroblastoma SK-N-MC cells PubMed
tat The function and activity of CREB is required for both Tat-induced Rho signaling and nuclear targeting of ZO-1 PubMed
tat HIV-1 Tat increases both CREB phosphorylation and DNA binding by 7- to 10-fold within 2 hours after stimulation in hematopoietic progenitor cells PubMed
tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat The CKLF-like MARVEL transmembrane domain-containing family 2 (CMTM2) blocks HIV-1 Tat-induced AP-1 and CREB activation, which leads to suppress HIV-1 provirus transcription PubMed
tat HIV-1 Tat upregulates IL-10 synthesis by ERK MAPK-dependent CREB-1 transcription factor activation through Ser(133) phosphorylation PubMed
tat HIV-1 Tat protein downregulates the Ser-133 phosphorylation, activation, and expression of CREB transcription factor in PC12 neuronal cells through sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed
tat Extracellular HIV-1 Tat protein induces the rapid Ser-133 phosphorylation and activation of CREB transcription factor in lymphoid cells through a signal cascade involving the MAPK pathway PubMed
Vpr vpr The RNA and protein levels of cAMP responsive element binding protein (CREB) decreases in Vpr-treated human neurons compared to the untreated control PubMed
matrix gag HIV-1 MA increases phosphorylation and the DNA-binding activity of CREB and c-Myc through activation of the cAMP/PKA and MEK/ERK signaling pathways. Both signaling pathways are synergistically activated upon co-stimulation through the CD19 receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9284

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription activator activity, RNA polymerase II-specific ISS
Inferred from Sequence or Structural Similarity
more info
 
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
DNA-binding transcription factor activity, RNA polymerase II-specific ISM
Inferred from Sequence Model
more info
PubMed 
Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription coactivator binding IEA
Inferred from Electronic Annotation
more info
 
arrestin family protein binding IEA
Inferred from Electronic Annotation
more info
 
cAMP response element binding IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone acetyltransferase binding IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
axonogenesis IEA
Inferred from Electronic Annotation
more info
 
cellular response to fatty acid IEA
Inferred from Electronic Annotation
more info
 
cellular response to hepatocyte growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to insulin-like growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to nerve growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to platelet-derived growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to retinoic acid ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to zinc ion IEA
Inferred from Electronic Annotation
more info
 
chemotaxis to arachidonic acid IEA
Inferred from Electronic Annotation
more info
 
circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
lactation IEA
Inferred from Electronic Annotation
more info
 
lung saccule development IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription by competitive promoter binding IDA
Inferred from Direct Assay
more info
PubMed 
pituitary gland development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hormone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of transforming growth factor beta3 production IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell size IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
regulation of fibroblast proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of glial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
response to L-glutamate IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to glucagon ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
response to nicotine IEA
Inferred from Electronic Annotation
more info
 
response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule organization IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
type I pneumocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
ATF4-CREB1 transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
axon IEA
Inferred from Electronic Annotation
more info
 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cyclic AMP-responsive element-binding protein 1
Names
active transcription factor CREB
cAMP-response element-binding protein-1
cyclic adenosine 3',5'-monophosphate response element binding protein
cyclic adenosine 3',5'-monophosphate response element-binding protein CREB
transactivator protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023299.1 RefSeqGene

    Range
    5071..81097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001320793.2NP_001307722.1  cyclic AMP-responsive element-binding protein 1 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (C) lacks an alternate internal segment and has a shorter and distinct C-terminus compared to isoform B.
    Source sequence(s)
    AC009298, AK298740, DC366797
    UniProtKB/TrEMBL
    B7Z5C6
    Conserved Domains (1) summary
    pfam02173
    Location:99137
    pKID; pKID domain
  2. NM_001371426.1NP_001358355.1  cyclic AMP-responsive element-binding protein 1 isoform B

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain
  3. NM_001371427.1NP_001358356.1  cyclic AMP-responsive element-binding protein 1 isoform A

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Related
    ENSP00000405539.1, ENST00000430624.5
    Conserved Domains (2) summary
    cd14690
    Location:271325
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:99137
    pKID; pKID domain
  4. NM_001371428.1NP_001358357.1  cyclic AMP-responsive element-binding protein 1 isoform D

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
    Related
    ENSP00000405711.1, ENST00000448277.5
    Conserved Domains (2) summary
    cd14690
    Location:231285
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:5997
    pKID; pKID domain
  5. NM_004379.5NP_004370.1  cyclic AMP-responsive element-binding protein 1 isoform A

    See identical proteins and their annotated locations for NP_004370.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as A) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (A) has the same N- and C-termini but is shorter compared to isoform B.
    Source sequence(s)
    AC079767, BC095407, BU154326
    Consensus CDS
    CCDS2374.1
    UniProtKB/Swiss-Prot
    P16220
    UniProtKB/TrEMBL
    Q53X93
    Related
    ENSP00000236995.3, ENST00000353267.8
    Conserved Domains (2) summary
    cd14690
    Location:271325
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:99137
    pKID; pKID domain
  6. NM_134442.5NP_604391.1  cyclic AMP-responsive element-binding protein 1 isoform B

    See identical proteins and their annotated locations for NP_604391.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as B) represents the longest transcript and encodes the longest isoform (B).
    Source sequence(s)
    AC079767, BC010636, BU154326, DC366797
    Consensus CDS
    CCDS2375.1
    UniProtKB/Swiss-Prot
    P16220
    UniProtKB/TrEMBL
    Q5U0J5
    Related
    ENSP00000387699.2, ENST00000432329.6
    Conserved Domains (2) summary
    cd14690
    Location:285339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:113151
    pKID; pKID domain

RNA

  1. NR_135473.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment in the 3' end compared to variant 2. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC079767, BC010636, BU154326, DC366797, HY204508
  2. NR_163946.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767
  3. NR_163947.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC009298, AC079767

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    207529943..207605988
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510646.3XP_011508948.1  cyclic AMP-responsive element-binding protein 1 isoform X2

    Conserved Domains (1) summary
    pfam02173
    Location:113151
    pKID; pKID domain
  2. XM_011510648.3XP_011508950.1  cyclic AMP-responsive element-binding protein 1 isoform X4

    Conserved Domains (1) summary
    pfam02173
    Location:113151
    pKID; pKID domain
  3. XM_017003399.2XP_016858888.1  cyclic AMP-responsive element-binding protein 1 isoform X6

  4. XM_011510650.3XP_011508952.1  cyclic AMP-responsive element-binding protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011508952.1

    Conserved Domains (2) summary
    cd14690
    Location:245299
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:73111
    pKID; pKID domain
  5. XM_017003401.2XP_016858890.1  cyclic AMP-responsive element-binding protein 1 isoform X8

    Conserved Domains (1) summary
    cd14690
    Location:55109
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

RNA

  1. XR_001738636.2 RNA Sequence

  2. XR_241290.2 RNA Sequence

  3. XR_241292.2 RNA Sequence

  4. XR_001738637.2 RNA Sequence

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