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Ephb6 Eph receptor B6 [ Mus musculus (house mouse) ]

Gene ID: 13848, updated on 9-Mar-2023

Summary

Official Symbol
Ephb6provided by MGI
Official Full Name
Eph receptor B6provided by MGI
Primary source
MGI:MGI:1096338
See related
Ensembl:ENSMUSG00000029869 AllianceGenome:MGI:1096338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mep; Cekl
Summary
Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 56.8), cortex adult (RPKM 24.8) and 15 other tissues See more
Orthologs
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Genomic context

See Ephb6 in Genome Data Viewer
Location:
6; 6 B2.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41580768..41597445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41603834..41620509)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene predicted gene, 38795 Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene predicted gene, 34642 Neighboring gene transient receptor potential cation channel, subfamily V, member 5

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin type-B receptor 6
Names
chicken eph/elk receptor-like protein
ephrin type A receptor
tyrosine-protein kinase-defective receptor EPH-6
NP_001139823.1
NP_031706.3
XP_030111004.1
XP_036021700.1
XP_036021701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146351.2NP_001139823.1  ephrin type-B receptor 6 precursor

    See identical proteins and their annotated locations for NP_001139823.1

    Status: VALIDATED

    Source sequence(s)
    AC117678
    Consensus CDS
    CCDS20051.1
    UniProtKB/Swiss-Prot
    O08644, Q8K0A9
    Related
    ENSMUSP00000110380.3, ENSMUST00000114732.3
    Conserved Domains (8) summary
    cd09555
    Location:9381006
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    smart00454
    Location:9391005
    SAM; Sterile alpha motif
    cd10475
    Location:34226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:481572
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305340
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:663908
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:605658
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:658912
    PKc_like; Protein Kinases, catalytic domain
  2. NM_007680.5NP_031706.3  ephrin type-B receptor 6 precursor

    See identical proteins and their annotated locations for NP_031706.3

    Status: VALIDATED

    Source sequence(s)
    AC117678
    Consensus CDS
    CCDS20051.1
    UniProtKB/Swiss-Prot
    O08644, Q8K0A9
    Conserved Domains (8) summary
    cd09555
    Location:9381006
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    smart00454
    Location:9391005
    SAM; Sterile alpha motif
    cd10475
    Location:34226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:481572
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305340
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:663908
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:605658
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:658912
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_166495.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117678

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    41580768..41597445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255144.2XP_030111004.1  ephrin type-B receptor 6 isoform X1

    Conserved Domains (7) summary
    cd09555
    Location:10021070
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:545636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:366464
    fn3; Fibronectin type III domain
    pfam14575
    Location:669722
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:722976
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036165807.1XP_036021700.1  ephrin type-B receptor 6 isoform X2

    Conserved Domains (6) summary
    cd09555
    Location:9461014
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    pfam00041
    Location:546628
    fn3; Fibronectin type III domain
    pfam07699
    Location:305340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:618668
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:666920
    PKc_like; Protein Kinases, catalytic domain
  3. XM_036165808.1XP_036021701.1  ephrin type-B receptor 6 isoform X3

    Conserved Domains (6) summary
    cd09555
    Location:882950
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    pfam00041
    Location:482564
    fn3; Fibronectin type III domain
    pfam07699
    Location:305340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:554604
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:602856
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003956161.2 RNA Sequence