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Ephb6 Eph receptor B6 [ Mus musculus (house mouse) ]

Gene ID: 13848, updated on 9-Mar-2023

Summary

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Official Symbol
Ephb6provided by MGI
Official Full Name
Eph receptor B6provided by MGI
Primary source
MGI:MGI:1096338
See related
Ensembl:ENSMUSG00000029869 AllianceGenome:MGI:1096338
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mep; Cekl
Summary
Predicted to enable transmembrane-ephrin receptor activity. Acts upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Located in cell surface. Is expressed in several structures, including alimentary system; central nervous system; integumental system; intraembryonic coelom; and sensory organ. Orthologous to human EPHB6 (EPH receptor B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 56.8), cortex adult (RPKM 24.8) and 15 other tissues See more
Orthologs
human all
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Genomic context

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See Ephb6 in Genome Data Viewer
Location:
6; 6 B2.1
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (41580768..41597445)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (41603834..41620509)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene T cell receptor beta chain Neighboring gene T cell receptor beta, variable 31 Neighboring gene predicted gene, 27549 Neighboring gene predicted gene, 38795 Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene predicted gene, 34642 Neighboring gene transient receptor potential cation channel, subfamily V, member 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells. Shi W, et al. J Biol Chem, 2020 May 29. PMID 32321761, Free PMC Article
  2. EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells. Shi W, et al. J Biol Chem, 2019 Apr 26. PMID 30824540, Free PMC Article
  3. EPHB6 and testosterone in concert regulate epinephrine release by adrenal gland chromaffin cells. Wang Y, et al. Sci Rep, 2018 Jan 16. PMID 29339804, Free PMC Article
  4. Acute DSS colitis alters EphB6 receptor expression in neurons of the spinal dorsal horn. King DE. Neurosci Lett, 2014 Jan 24. PMID 24309292
  5. Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice. Shimoyama M, et al. Biochem Biophys Res Commun, 2002 Oct 18. PMID 12379224

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells.
    Title: The receptor tyrosine kinase EPHB6 regulates catecholamine exocytosis in adrenal gland chromaffin cells.
  2. findings elucidate the mechanisms by which EPHB6 modulates catecholamine (CAT) biosynthesis and identify potential therapeutic targets for diseases, such as hypertension, caused by dysfunctional CAT biosynthesis
    Title: EPHB6 controls catecholamine biosynthesis by up-regulating tyrosine hydroxylase transcription in adrenal gland chromaffin cells.
  3. using an EphB6 mouse knockout model we found that the loss of EphB6 does not initiate intestinal tumorigenesis and is not involved in the early tumor progression through the adenoma-to-carcinoma transition.
    Title: Loss of the EPH receptor B6 contributes to colorectal cancer metastasis.
  4. Colitis significantly downregulates Ephb6 expression in the neurons of the spinal dorsal horn.
    Title: Acute DSS colitis alters EphB6 receptor expression in neurons of the spinal dorsal horn.
  5. Ephs and Efns, in concert with testosterone, play a critical role in regulating small artery contractility and blood pressure.
    Title: Receptor tyrosine kinase Ephb6 regulates vascular smooth muscle contractility and modulates blood pressure in concert with sex hormones.
  6. T-cell development in EphB6 knockout mice
    Title: Developmental expression of EphB6 in the thymus: lessons from EphB6 knockout mice.
  7. EphB6 is pivotal in T cell function as shown by its null mutation
    Title: EphB6-null mutation results in compromised T cell function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within positive regulation of T cell costimulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within type IV hypersensitivity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ephrin type-B receptor 6
Names
chicken eph/elk receptor-like protein
ephrin type A receptor
tyrosine-protein kinase-defective receptor EPH-6
NP_001139823.1
NP_031706.3
XP_030111004.1
XP_036021700.1
XP_036021701.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146351.2 → NP_001139823.1  ephrin type-B receptor 6 precursor

    See identical proteins and their annotated locations for NP_001139823.1

    Status: VALIDATED

    Source sequence(s)
    AC117678
    Consensus CDS
    CCDS20051.1
    UniProtKB/Swiss-Prot
    O08644, Q8K0A9
    Related
    ENSMUSP00000110380.3, ENSMUST00000114732.3
    Conserved Domains (8) summary
    cd09555
    Location:938 → 1006
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    smart00454
    Location:939 → 1005
    SAM; Sterile alpha motif
    cd10475
    Location:34 → 226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:481 → 572
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305 → 340
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:663 → 908
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:605 → 658
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:658 → 912
    PKc_like; Protein Kinases, catalytic domain

  2. NM_007680.5 → NP_031706.3  ephrin type-B receptor 6 precursor

    See identical proteins and their annotated locations for NP_031706.3

    Status: VALIDATED

    Source sequence(s)
    AC117678
    Consensus CDS
    CCDS20051.1
    UniProtKB/Swiss-Prot
    O08644, Q8K0A9
    Conserved Domains (8) summary
    cd09555
    Location:938 → 1006
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    smart00454
    Location:939 → 1005
    SAM; Sterile alpha motif
    cd10475
    Location:34 → 226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:481 → 572
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305 → 340
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:663 → 908
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:605 → 658
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:658 → 912
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_166495.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC117678

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    41580768..41597445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255144.2 → XP_030111004.1  ephrin type-B receptor 6 isoform X1

    Conserved Domains (7) summary
    cd09555
    Location:1002 → 1070
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34 → 226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:545 → 636
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:305 → 340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:366 → 464
    fn3; Fibronectin type III domain
    pfam14575
    Location:669 → 722
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:722 → 976
    PKc_like; Protein Kinases, catalytic domain

  2. XM_036165807.1 → XP_036021700.1  ephrin type-B receptor 6 isoform X2

    Conserved Domains (6) summary
    cd09555
    Location:946 → 1014
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34 → 226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    pfam00041
    Location:546 → 628
    fn3; Fibronectin type III domain
    pfam07699
    Location:305 → 340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:618 → 668
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:666 → 920
    PKc_like; Protein Kinases, catalytic domain

  3. XM_036165808.1 → XP_036021701.1  ephrin type-B receptor 6 isoform X3

    Conserved Domains (6) summary
    cd09555
    Location:882 → 950
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    cd10475
    Location:34 → 226
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    pfam00041
    Location:482 → 564
    fn3; Fibronectin type III domain
    pfam07699
    Location:305 → 340
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam14575
    Location:554 → 604
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:602 → 856
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_003956161.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08644.4 GenPept UniProtKB/Swiss-Prot:O08644

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