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PIP5KL1 phosphatidylinositol-4-phosphate 5-kinase like 1 [ Homo sapiens (human) ]

Gene ID: 138429, updated on 1-Jun-2020

Summary

Official Symbol
PIP5KL1provided by HGNC
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase like 1provided by HGNC
Primary source
HGNC:HGNC:28711
See related
Ensembl:ENSG00000167103 MIM:612865
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIPKH
Summary
PIP5KL1 is a phosphoinositide kinase-like protein that lacks intrinsic lipid kinase activity but associates with type I PIPKs (see PIP5K1A; MIM 603275) and may play a role in localization of PIPK activity (Chang et al., 2004 [PubMed 14701839]).[supplied by OMIM, Jun 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See PIP5KL1 in Genome Data Viewer
Location:
9q34.11
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127920881..127931958, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130683808..130693076, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene adenylate kinase 1 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 Neighboring gene ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 Neighboring gene dolichyl-phosphate mannosyltransferase subunit 2, regulatory Neighboring gene family with sequence similarity 102 member A Neighboring gene Sharpr-MPRA regulatory region 6856

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46424

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
phosphatidylinositol 4-phosphate 5-kinase-like protein 1
Names
PI(4)P 5-kinase-like protein 1
phosphatidylinositol phosphate kinase homolog
ptdIns(4)P-5-kinase-like protein 1
NP_001128691.1
NP_775763.1
XP_016869768.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135219.2NP_001128691.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001128691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL157935, BC042184, BE881330
    Consensus CDS
    CCDS48030.1
    UniProtKB/Swiss-Prot
    Q5T9C9
    Related
    ENSP00000373399.4, ENST00000388747.9
    Conserved Domains (1) summary
    pfam01504
    Location:128392
    PIP5K; Phosphatidylinositol-4-phosphate 5-Kinase
  2. NM_173492.1NP_775763.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_775763.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons and has an alternate 5' segment, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    BC042184
    Consensus CDS
    CCDS6885.1
    UniProtKB/Swiss-Prot
    Q5T9C9
    Related
    ENSP00000300432.3, ENST00000300432.3
    Conserved Domains (1) summary
    pfam01504
    Location:1189
    PIP5K; Phosphatidylinositol-4-phosphate 5-Kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127920881..127931958 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017014279.1XP_016869768.1  phosphatidylinositol 4-phosphate 5-kinase-like protein 1 isoform X1

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