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PTRH1 peptidyl-tRNA hydrolase 1 homolog [ Homo sapiens (human) ]

Gene ID: 138428, updated on 24-Nov-2020

Summary

Official Symbol
PTRH1provided by HGNC
Official Full Name
peptidyl-tRNA hydrolase 1 homologprovided by HGNC
Primary source
HGNC:HGNC:27039
See related
Ensembl:ENSG00000187024
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PTH1; C9orf115
Expression
Broad expression in kidney (RPKM 2.9), testis (RPKM 2.7) and 25 other tissues See more
Orthologs

Genomic context

See PTRH1 in Genome Data Viewer
Location:
9q34.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (127691923..127715676, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130476227..130487152, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 1 Neighboring gene VISTA enhancer hs2342 Neighboring gene microRNA 3911 Neighboring gene cilia and flagella associated protein 157 Neighboring gene tetratricopeptide repeat domain 16 Neighboring gene Sharpr-MPRA regulatory region 4083 Neighboring gene torsin family 2 member A Neighboring gene SH2 domain containing 3C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC51999

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
probable peptidyl-tRNA hydrolase
Names
PTH
NP_001002913.1
NP_001332906.1
NP_001332907.1
NP_001332908.1
NP_001332909.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002913.3NP_001002913.1  probable peptidyl-tRNA hydrolase isoform 1

    See identical proteins and their annotated locations for NP_001002913.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC047012, BQ045289, DB141384
    Consensus CDS
    CCDS35147.1
    UniProtKB/Swiss-Prot
    Q86Y79
    Related
    ENSP00000439469.1, ENST00000543175.5
    Conserved Domains (1) summary
    cd00462
    Location:32203
    PTH; Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through ...
  2. NM_001345977.1NP_001332906.1  probable peptidyl-tRNA hydrolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AV709373, BC015230, BQ045289, DB141384
    Related
    ENSP00000485347.1, ENST00000456267.5
  3. NM_001345978.1NP_001332907.1  probable peptidyl-tRNA hydrolase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL162426
    Consensus CDS
    CCDS87693.1
    UniProtKB/TrEMBL
    C9J7Z1
    Related
    ENSP00000418219.1, ENST00000423807.5
  4. NM_001345979.1NP_001332908.1  probable peptidyl-tRNA hydrolase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC015230, BM691270, BQ045289, DB141384
    Related
    ENSP00000485479.1, ENST00000414832.2
  5. NM_001345980.1NP_001332909.1  probable peptidyl-tRNA hydrolase isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks two alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (5) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC015230, BE295757, BQ045289, DB141384

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    127691923..127715676 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_002956760.1 RNA Sequence

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