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Epha7 Eph receptor A7 [ Mus musculus (house mouse) ]

Gene ID: 13841, updated on 5-Jan-2023

Summary

Official Symbol
Epha7provided by MGI
Official Full Name
Eph receptor A7provided by MGI
Primary source
MGI:MGI:95276
See related
Ensembl:ENSMUSG00000028289 AllianceGenome:MGI:95276
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ebk; Ehk3; Mdk1; Cek11; Hek11
Summary
Enables chemorepellent activity; growth factor binding activity; and transmembrane signaling receptor activity. Involved in several processes, including ephrin receptor signaling pathway; negative regulation of nervous system development; and regulation of protein phosphorylation. Acts upstream of or within nephric duct morphogenesis; nervous system development; and positive regulation of neuron apoptotic process. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; foot bone; genitourinary system; and sensory organ. Orthologous to human EPHA7 (EPH receptor A7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 6.7), CNS E11.5 (RPKM 6.2) and 10 other tissues See more
Orthologs
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Genomic context

See Epha7 in Genome Data Viewer
Location:
4 A4; 4 12.42 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (28811840..28969391)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (28813066..28967503)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene macrophage migration inhibitory factor, pseudogene 11 Neighboring gene predicted gene 11909 Neighboring gene predicted gene 11917 Neighboring gene predicted gene, 52716

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GPI-linked ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables axon guidance receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of chemical synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in modulation of chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of collateral sprouting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nephric duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within retinal ganglion cell axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in hippocampal mossy fiber to CA3 synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IC
Inferred by Curator
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ephrin type-A receptor 7
Names
EPH homology kinase 3
developmental kinase 1
embryonic brain kinase
NP_001116361.1
NP_001277363.1
NP_034271.3
XP_006537669.1
XP_006537670.1
XP_017175443.1
XP_036019542.1
XP_036019543.1
XP_036019544.1
XP_036019545.1
XP_036019546.1
XP_036019547.1
XP_036019548.1
XP_036019549.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122889.1NP_001116361.1  ephrin type-A receptor 7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001116361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a different and shorter C-terminus, as compared to isoform 1.
    Source sequence(s)
    AK033903, CN702163
    Consensus CDS
    CCDS51132.1
    UniProtKB/TrEMBL
    Q8CC52
    Related
    ENSMUSP00000079735.5, ENSMUST00000080934.11
    Conserved Domains (4) summary
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:333427
    fn3; Fibronectin type III domain
    pfam07699
    Location:275312
    GCC2_GCC3; GCC2 and GCC3
  2. NM_001290434.1NP_001277363.1  ephrin type-A receptor 7 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AK030480, AK033903, BX000989
    Consensus CDS
    CCDS71353.1
    UniProtKB/Swiss-Prot
    Q61772
    UniProtKB/TrEMBL
    A2BDQ4, Q8CC52
    Related
    ENSMUSP00000103826.2, ENSMUST00000108191.2
    Conserved Domains (7) summary
    cd09548
    Location:915984
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    smart00454
    Location:916983
    SAM; Sterile alpha motif
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:624890
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:629886
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:565624
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. NM_010141.4NP_034271.3  ephrin type-A receptor 7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034271.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK030480, AK033903, BX000989
    Consensus CDS
    CCDS18013.1
    UniProtKB/Swiss-Prot
    Q61772, Q8BSU8
    UniProtKB/TrEMBL
    Q8CC52
    Related
    ENSMUSP00000029964.6, ENSMUST00000029964.12
    Conserved Domains (7) summary
    cd09548
    Location:919988
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    smart00454
    Location:920987
    SAM; Sterile alpha motif
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:628894
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07714
    Location:633890
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:565628
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    28811840..28969391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537607.5XP_006537670.1  ephrin type-A receptor 7 isoform X9

    See identical proteins and their annotated locations for XP_006537670.1

    UniProtKB/Swiss-Prot
    Q61772
    Related
    ENSMUSP00000103829.3, ENSMUST00000108194.9
    Conserved Domains (3) summary
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:275312
    Ephrin_rec_like; Putative ephrin-receptor like
  2. XM_006537606.5XP_006537669.1  ephrin type-A receptor 7 isoform X5

    UniProtKB/Swiss-Prot
    Q61772
    Conserved Domains (5) summary
    cd09548
    Location:914983
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:623889
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:562623
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  3. XM_036163653.1XP_036019546.1  ephrin type-A receptor 7 isoform X6

    Conserved Domains (5) summary
    cd09548
    Location:910979
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:619885
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:560621
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  4. XM_017319954.3XP_017175443.1  ephrin type-A receptor 7 isoform X8

    Conserved Domains (4) summary
    cd10485
    Location:30206
    EphR_LBD_A7; Ligand Binding Domain of Ephrin type-A Receptor 7
    cd00063
    Location:443534
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07699
    Location:275312
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:333421
    fn3; Fibronectin type III domain
  5. XM_036163651.1XP_036019544.1  ephrin type-A receptor 7 isoform X3

    Conserved Domains (5) summary
    cd09548
    Location:838907
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:547813
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:484549
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  6. XM_036163652.1XP_036019545.1  ephrin type-A receptor 7 isoform X4

    Conserved Domains (5) summary
    cd09548
    Location:834903
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:543809
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:484545
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  7. XM_036163649.1XP_036019542.1  ephrin type-A receptor 7 isoform X1

    Conserved Domains (5) summary
    cd09548
    Location:843912
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:552818
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:489554
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  8. XM_036163650.1XP_036019543.1  ephrin type-A receptor 7 isoform X2

    Conserved Domains (5) summary
    cd09548
    Location:839908
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:548814
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:489550
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  9. XM_036163656.1XP_036019549.1  ephrin type-A receptor 7 isoform X7

    Conserved Domains (4) summary
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:257351
    fn3; Fibronectin type III domain
    pfam07699
    Location:199236
    Ephrin_rec_like; Putative ephrin-receptor like
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  10. XM_036163654.1XP_036019547.1  ephrin type-A receptor 7 isoform X1

    Conserved Domains (5) summary
    cd09548
    Location:843912
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:552818
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:489554
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  11. XM_036163655.1XP_036019548.1  ephrin type-A receptor 7 isoform X1

    Conserved Domains (5) summary
    cd09548
    Location:843912
    SAM_EPH-A7; SAM domain of EPH-A7 subfamily of tyrosine kinase receptors
    cd00063
    Location:367458
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:552818
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam14575
    Location:489554
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1130
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

RNA

  1. XR_004941807.1 RNA Sequence

  2. XR_004941806.1 RNA Sequence

  3. XR_004941808.1 RNA Sequence