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Epha6 Eph receptor A6 [ Mus musculus (house mouse) ]

Gene ID: 13840, updated on 23-Jun-2021

Summary

Official Symbol
Epha6provided by MGI
Official Full Name
Eph receptor A6provided by MGI
Primary source
MGI:MGI:108034
See related
Ensembl:ENSMUSG00000055540
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ehk2; Hek12; m-ehk2
Expression
Biased expression in frontal lobe adult (RPKM 1.8), cortex adult (RPKM 1.3) and 5 other tissues See more
Orthologs
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Genomic context

See Epha6 in Genome Data Viewer
Location:
16; 16 C1.3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (59473424..60431196, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (59641433..60610911, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (59653309..60605357, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930547E14 gene Neighboring gene beta-gamma crystallin domain containing 3 Neighboring gene ribosomal oxygenase 2 Neighboring gene ADP-ribosylation factor-like 6 Neighboring gene predicted gene 4660 Neighboring gene predicted gene 9017 Neighboring gene predicted gene, 23852 Neighboring gene protein FAM60A-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 6
Names
EHK-2
EPH homology kinase 2
NP_031964.2
XP_006521850.1
XP_011244128.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007938.2NP_031964.2  ephrin type-A receptor 6

    See identical proteins and their annotated locations for NP_031964.2

    Status: VALIDATED

    Source sequence(s)
    AC118603, AC122318, AC131707, AC133940, AC134526, AC154212, AC154473, AC154632, CT009682
    Consensus CDS
    CCDS28260.2
    UniProtKB/TrEMBL
    G1K381
    Related
    ENSMUSP00000066734.7, ENSMUST00000068860.13
    Conserved Domains (9) summary
    cd09547
    Location:10551118
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    smart00454
    Location:10521119
    SAM; Sterile alpha motif
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
    cd00063
    Location:549628
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:7201028
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:427521
    fn3; Fibronectin type III domain
    pfam07699
    Location:370406
    GCC2_GCC3; GCC2 and GCC3
    pfam07714
    Location:7251024
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:648720
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    59473424..60431196 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521787.4XP_006521850.1  ephrin type-A receptor 6 isoform X1

    Conserved Domains (7) summary
    cd09547
    Location:899962
    SAM_EPH-A6; SAM domain of EPH-A6 subfamily of tyrosine kinase receptors
    cd00063
    Location:393472
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:564872
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam07699
    Location:214250
    Ephrin_rec_like; Putative ephrin-receptor like
    pfam00041
    Location:271361
    fn3; Fibronectin type III domain
    pfam14575
    Location:492564
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1144
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
  2. XM_011245826.4XP_011244128.1  ephrin type-A receptor 6 isoform X2

    Conserved Domains (1) summary
    cd10484
    Location:128300
    EphR_LBD_A6; Ligand Binding Domain of Ephrin type-A Receptor 6
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