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Epha3 Eph receptor A3 [ Mus musculus (house mouse) ]

Gene ID: 13837, updated on 8-Jul-2018
Official Symbol
Epha3provided by MGI
Official Full Name
Eph receptor A3provided by MGI
Primary source
MGI:MGI:99612
See related
Ensembl:ENSMUSG00000052504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EK4; Hek; Cek4; ETK1; End3; Hek4; Mek4; Tyro4; AW492086
Expression
Biased expression in CNS E11.5 (RPKM 8.7), CNS E14 (RPKM 8.4) and 11 other tissues See more
Orthologs
See Epha3 in Genome Data Viewer
Location:
16; 16 C1.3
Exon count:
17
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (63545218..63864157, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (63545044..63863983, complement)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene zinc finger and SCAN domain containing 5B pseudogene Neighboring gene predicted gene, 33912 Neighboring gene predicted gene, 41466 Neighboring gene casein kinase 2, alpha prime interacting protein Neighboring gene RIKEN cDNA 4930453N24 gene

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GPI-linked ephrin receptor activity ISO
Inferred from Sequence Orthology
more info
 
MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ephrin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
endocardial cushion development IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
fasciculation of motor neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
fasciculation of sensory neuron axon IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
ephrin type-A receptor 3
Names
EPH-like kinase 4
tyrosine-protein kinase TYRO4
tyrosine-protein kinase receptor ETK1
NP_034270.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362452.1NP_001349381.1  ephrin type-A receptor 3 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK089119, AW491216, BC093483, BC145349
    Conserved Domains (6) summary
    cd09544
    Location:912974
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    cd10481
    Location:29201
    EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3
    cd00063
    Location:437527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:616882
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:327417
    fn3; Fibronectin type III domain
    pfam14575
    Location:564616
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
  2. NM_010140.4NP_034270.1  ephrin type-A receptor 3 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034270.1

    Status: VALIDATED

    Source sequence(s)
    AC154568, AC154844, AC155275
    Consensus CDS
    CCDS28264.1
    UniProtKB/TrEMBL
    Q8BRB1
    Related
    ENSMUSP00000066554.6, ENSMUST00000064405.6
    Conserved Domains (8) summary
    cd09544
    Location:913975
    SAM_EPH-A3; SAM domain of EPH-A3 subfamily of tyrosine kinase receptors
    smart00454
    Location:909976
    SAM; Sterile alpha motif
    cd10481
    Location:29201
    EphR_LBD_A3; Ligand Binding Domain of Ephrin type-A Receptor 3
    cd00063
    Location:437528
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05066
    Location:617883
    PTKc_EphR_A; Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors
    pfam00041
    Location:327417
    fn3; Fibronectin type III domain
    pfam07714
    Location:622879
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:566617
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

    Range
    63545218..63864157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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