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Epha2 Eph receptor A2 [ Mus musculus (house mouse) ]

Gene ID: 13836, updated on 8-Dec-2022

Summary

Official Symbol
Epha2provided by MGI
Official Full Name
Eph receptor A2provided by MGI
Primary source
MGI:MGI:95278
See related
Ensembl:ENSMUSG00000006445 AllianceGenome:MGI:95278
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eck; Myk2; Sek2; Sek-2
Summary
Predicted to enable growth factor binding activity and transmembrane-ephrin receptor activity. Involved in several processes, including animal organ development; osteoblast differentiation; and regulation of blood vessel endothelial cell migration. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and notochord development. Located in cell surface. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; endometrium; and limb. Used to study cataract 6 multiple types. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Orthologous to human EPHA2 (EPH receptor A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 25.3), small intestine adult (RPKM 22.7) and 19 other tissues See more
Orthologs
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Genomic context

See Epha2 in Genome Data Viewer
Location:
4 D3; 4 73.67 cM
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141028532..141056695)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141301221..141329384)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 19 Neighboring gene predicted gene, 52686 Neighboring gene predicted gene 13056 Neighboring gene predicted gene 13076 Neighboring gene family with sequence similarity 131, member C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular function activator activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within axial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in cell motility ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
involved_in keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in lens fiber cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within notochord formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pericyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in response to growth factor ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in leading edge membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in tight junction ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ephrin type-A receptor 2
Names
epithelial cell kinase
tyrosine-protein kinase receptor ECK
tyrosine-protein kinase receptor MPK-5
tyrosine-protein kinase receptor SEK-2
NP_034269.2
XP_006538591.1
XP_036019541.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010139.3NP_034269.2  ephrin type-A receptor 2 precursor

    See identical proteins and their annotated locations for NP_034269.2

    Status: VALIDATED

    Source sequence(s)
    AK144202, AW457468, CJ088701
    Consensus CDS
    CCDS18869.1
    UniProtKB/Swiss-Prot
    Q03145, Q62212
    Related
    ENSMUSP00000006614.3, ENSMUST00000006614.3
    Conserved Domains (8) summary
    cd09543
    Location:903972
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:903969
    SAM; Sterile alpha motif
    cd10480
    Location:27200
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    cd00063
    Location:440527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:331425
    fn3; Fibronectin type III domain
    pfam07714
    Location:618872
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579609
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:608876
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141028532..141056695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163648.1XP_036019541.1  ephrin type-A receptor 2 isoform X1

    Conserved Domains (4) summary
    cd09543
    Location:655724
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:191272
    fn3; Fibronectin type III domain
    pfam14575
    Location:322363
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:360628
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006538528.5XP_006538591.1  ephrin type-A receptor 2 isoform X2

    Conserved Domains (4) summary
    cd09543
    Location:629698
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:165243
    fn3; Fibronectin type III domain
    pfam14575
    Location:298335
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:334602
    PKc_like; Protein Kinases, catalytic domain