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Epha2 Eph receptor A2 [ Mus musculus (house mouse) ]

Gene ID: 13836, updated on 12-Aug-2018

Summary

Official Symbol
Epha2provided by MGI
Official Full Name
Eph receptor A2provided by MGI
Primary source
MGI:MGI:95278
See related
Ensembl:ENSMUSG00000006445 Vega:OTTMUSG00000010200
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Eck; Myk2; Sek2; Sek-2; AW545284
Expression
Broad expression in lung adult (RPKM 25.3), small intestine adult (RPKM 22.7) and 19 other tissues See more
Orthologs

Genomic context

See Epha2 in Genome Data Viewer
Location:
4 D3; 4 73.67 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (141301221..141329384)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (140857155..140885293)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor (GEF) 19 Neighboring gene predicted gene 13056 Neighboring gene predicted gene 13076 Neighboring gene family with sequence similarity 131, member C

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Axon guidance, organism-specific biosystem (from KEGG)
    Axon guidance, organism-specific biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, conserved biosystem (from KEGG)
    Axon guidance, conserved biosystemAxon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are...
  • Axon guidance, organism-specific biosystem (from REACTOME)
    Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EPH-Ephrin signaling, organism-specific biosystem (from REACTOME)
    EPH-Ephrin signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EPH-ephrin mediated repulsion of cells, organism-specific biosystem (from REACTOME)
    EPH-ephrin mediated repulsion of cells, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • EPHA-mediated growth cone collapse, organism-specific biosystem (from REACTOME)
    EPHA-mediated growth cone collapse, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
    XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
axial mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel endothelial cell proliferation involved in sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
bone remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cell motility ISO
Inferred from Sequence Orthology
more info
 
defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
 
keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
lens fiber cell morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
mammary gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of lymphangiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord formation IGI
Inferred from Genetic Interaction
more info
PubMed 
notochord formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
pericyte cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell adhesion mediated by integrin ISO
Inferred from Sequence Orthology
more info
 
regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
response to growth factor ISO
Inferred from Sequence Orthology
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
focal adhesion ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
lamellipodium ISO
Inferred from Sequence Orthology
more info
 
leading edge membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin type-A receptor 2
Names
epithelial cell kinase
tyrosine-protein kinase receptor ECK
tyrosine-protein kinase receptor MPK-5
tyrosine-protein kinase receptor SEK-2
NP_034269.2
XP_006538591.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010139.3NP_034269.2  ephrin type-A receptor 2 precursor

    See identical proteins and their annotated locations for NP_034269.2

    Status: VALIDATED

    Source sequence(s)
    AK144202, AW457468, CJ088701
    Consensus CDS
    CCDS18869.1
    UniProtKB/Swiss-Prot
    Q03145
    Related
    ENSMUSP00000006614.2, OTTMUSP00000010843, ENSMUST00000006614.2, OTTMUST00000023711
    Conserved Domains (8) summary
    cd09543
    Location:903972
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:903969
    SAM; Sterile alpha motif
    cd10480
    Location:27200
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    cd00063
    Location:440527
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:331425
    fn3; Fibronectin type III domain
    pfam07714
    Location:618872
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:579609
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:608876
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

    Range
    141301221..141329384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538528.3XP_006538591.1  ephrin type-A receptor 2 isoform X1

    Conserved Domains (7) summary
    cd09543
    Location:629698
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    smart00454
    Location:629695
    SAM; Sterile alpha motif
    cd00063
    Location:166253
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:57151
    fn3; Fibronectin type III domain
    pfam07714
    Location:344598
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:305335
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:334602
    PKc_like; Protein Kinases, catalytic domain
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