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Stom stomatin [ Mus musculus (house mouse) ]

Gene ID: 13830, updated on 1-Mar-2024

Summary

Official Symbol
Stomprovided by MGI
Official Full Name
stomatinprovided by MGI
Primary source
MGI:MGI:95403
See related
Ensembl:ENSMUSG00000026880 AllianceGenome:MGI:95403
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epb7.2
Summary
Enables protein homodimerization activity. Involved in several processes, including positive regulation by host of viral genome replication; positive regulation of protein targeting to membrane; and regulation of acid-sensing ion channel activity. Located in mitochondrion and perinuclear region of cytoplasm. Is integral component of plasma membrane. Is expressed in bladder; gut; and liver lobe. Orthologous to human STOM (stomatin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in large intestine adult (RPKM 56.5), liver E14.5 (RPKM 49.9) and 27 other tissues See more
Orthologs
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Genomic context

See Stom in Genome Data Viewer
Location:
2 B; 2 23.53 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (35204002..35227021, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35313990..35337009, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene 13605 Neighboring gene predicted gene, 52553 Neighboring gene predicted gene, 39795 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:35128407-35128590 Neighboring gene gelsolin Neighboring gene STARR-positive B cell enhancer mm9_chr2:35192389-35192690 Neighboring gene glyoxalase 1, pseudogene Neighboring gene RIKEN cDNA 4930568D16 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ion channel inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
stomatin
Names
erythrocyte band 7 integral membrane protein
erythrocyte membrane protein band 7.2
erythrocyte protein band 7.2
erythrocyte protein band 7.2; protein 7.2b
protein 7.2b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013515.2NP_038543.1  stomatin

    See identical proteins and their annotated locations for NP_038543.1

    Status: PROVISIONAL

    Source sequence(s)
    AL773523
    Consensus CDS
    CCDS15961.1
    UniProtKB/Swiss-Prot
    O88988, P54116, Q3UP81, Q60744, Q62455
    UniProtKB/TrEMBL
    Q8BPA1
    Related
    ENSMUSP00000028241.7, ENSMUST00000028241.7
    Conserved Domains (2) summary
    smart00244
    Location:53204
    PHB; prohibitin homologues
    cd03403
    Location:73274
    SPFH_stomatin; Stomatin, a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    35204002..35227021 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)