U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Epb42 erythrocyte membrane protein band 4.2 [ Mus musculus (house mouse) ]

Gene ID: 13828, updated on 5-Jan-2023

Summary

Go to the top of the page Help
Official Symbol
Epb42provided by MGI
Official Full Name
erythrocyte membrane protein band 4.2provided by MGI
Primary source
MGI:MGI:95402
See related
Ensembl:ENSMUSG00000023216 AllianceGenome:MGI:95402
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epb4.2
Summary
The protein encoded by this gene is the key component of a macromolecular complex involved in the structure of erythrocytes. [provided by RefSeq, Aug 2015]
Expression
Biased expression in liver E14.5 (RPKM 57.9), liver E14 (RPKM 55.2) and 3 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Epb42 in Genome Data Viewer
Location:
2 E5; 2 60.37 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120848372..120867358, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (121017891..121036877, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein 62 Neighboring gene small nucleolar RNA, C/D box 3B, pseudogene 2 Neighboring gene cyclin D-type binding-protein 1 Neighboring gene WW domain binding protein 2 pseudogene Neighboring gene transglutaminase 5 Neighboring gene transglutaminase 7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Induction of erythrocyte protein 4.2 gene expression during differentiation of murine erythroleukemia cells. Karacay B, et al. Genomics, 1999 Jul 1. PMID 10395794
  2. Developmental expression of mouse erythrocyte protein 4.2 mRNA: evidence for specific expression in erythroid cells. Zhu L, et al. Blood, 1998 Jan 15. PMID 9427728
  3. Molecular cloning of mouse erythrocyte protein 4.2: a membrane protein with strong homology with the transglutaminase supergene family. Rybicki AC, et al. Mamm Genome, 1994 Jul. PMID 7919657
  4. The murine erythrocyte protein-4.2-encoding gene: similarities and differences in structure and expression from its human counterpart. Karacay B, et al. Gene, 1995 Jun 9. PMID 7607550
  5. Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes. Rivera A, et al. Am J Physiol Cell Physiol, 2006 Nov. PMID 16774987

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that a nuclear complex containing TAL1 and LIM domain-binding protein Ldb1 transactivates the protein 4.2 (P4.2) gene
    Title: Identification of a TAL1 target gene reveals a positive role for the LIM domain-binding protein Ldb1 in erythroid gene expression and differentiation.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-glutamine gamma-glutamyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within erythrocyte maturation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within hemoglobin metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within monoatomic ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptide cross-linking IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
acts_upstream_of_or_within regulation of cell shape IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spleen development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
protein 4.2; erythrocyte membrane protein band 4.2
Names
P4.2
erythrocyte protein 4.2
erythrocyte protein band 4.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013513.3 → NP_038541.1  protein 4.2

    See identical proteins and their annotated locations for NP_038541.1

    Status: REVIEWED

    Source sequence(s)
    AK133896, AK143841, BY230962
    Consensus CDS
    CCDS16631.1
    UniProtKB/Swiss-Prot
    P49222, Q3UP33
    Related
    ENSMUSP00000099548.4, ENSMUST00000102490.10
    Conserved Domains (3) summary
    smart00460
    Location:261 → 351
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:6 → 123
    Transglut_N; Transglutaminase family
    pfam00927
    Location:588 → 686
    Transglut_C; Transglutaminase family, C-terminal ig like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120848372..120867358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498727.3 → XP_006498790.1  erythrocyte membrane protein band 4.2 isoform X1

    Conserved Domains (3) summary
    smart00460
    Location:261 → 351
    TGc; Transglutaminase/protease-like homologues
    pfam00868
    Location:5 → 124
    Transglut_N; Transglutaminase family
    pfam00927
    Location:588 → 685
    Transglut_C; Transglutaminase family, C-terminal ig like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49222.3 GenPept UniProtKB/Swiss-Prot:P49222

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous