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Epb41l1 erythrocyte membrane protein band 4.1 like 1 [ Mus musculus (house mouse) ]

Gene ID: 13821, updated on 9-Sep-2018

Summary

Official Symbol
Epb41l1provided by MGI
Official Full Name
erythrocyte membrane protein band 4.1 like 1provided by MGI
Primary source
MGI:MGI:103010
See related
Ensembl:ENSMUSG00000027624 Vega:OTTMUSG00000015876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4.1N; NBL1; Epb4.1l1; mKIAA0338
Expression
Broad expression in cortex adult (RPKM 33.4), cerebellum adult (RPKM 32.7) and 20 other tissues See more
Orthologs

Genomic context

See Epb41l1 in Genome Data Viewer
Location:
2 H1; 2 77.39 cM
Exon count:
30
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (156420878..156543214)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (156246788..156368950)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900097C17 gene Neighboring gene predicted gene 14170 Neighboring gene ribosomal protein L37a pseudogene Neighboring gene predicted gene, 33977 Neighboring gene AAR2 splicing factor homolog Neighboring gene predicted gene 14169

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actomyosin structure organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
band 4.1-like protein 1
Names
erythrocyte protein band 4.1 like 1
neuronal protein 4.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006664.3NP_001006665.1  band 4.1-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001006665.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 all encode isoform a.
    Source sequence(s)
    AL929153, BF464311, CJ113617
    Consensus CDS
    CCDS16966.1
    UniProtKB/Swiss-Prot
    Q9Z2H5
    UniProtKB/TrEMBL
    A2AUK5
    Related
    ENSMUSP00000029155.8, ENSMUST00000029155.15
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:741866
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  2. NM_001291120.1NP_001278049.1  band 4.1-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_001278049.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 3 and 4 all encode isoform a.
    Source sequence(s)
    AK147611, AL929153, BF464311
    Consensus CDS
    CCDS16966.1
    UniProtKB/Swiss-Prot
    Q9Z2H5
    UniProtKB/TrEMBL
    A2AUK5
    Related
    ENSMUSP00000099426.3, OTTMUSP00000016920, ENSMUST00000103137.9, OTTMUST00000037731
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:741866
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  3. NM_001291121.1NP_001278050.1  band 4.1-like protein 1 isoform c

    See identical proteins and their annotated locations for NP_001278050.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AK147611, AL929153, BF464311
    Consensus CDS
    CCDS71169.1
    UniProtKB/TrEMBL
    A2AUK8
    Related
    ENSMUSP00000105205.2, OTTMUSP00000016924, ENSMUST00000109577.8, OTTMUST00000037736
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:482512
    SAB; SAB domain
    pfam05902
    Location:729854
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  4. NM_001291122.1NP_001278051.1  band 4.1-like protein 1 isoform d

    See identical proteins and their annotated locations for NP_001278051.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks two alternate in-frame exons in the central coding region, compared to variant 1. The encoded isoform (d) is shorter than isoform a.
    Source sequence(s)
    AK147611, AL929153, BF464311
    UniProtKB/Swiss-Prot
    Q9Z2H5
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:482512
    SAB; SAB domain
    pfam05902
    Location:593718
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  5. NM_001291123.1NP_001278052.1  band 4.1-like protein 1 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, and uses an alternate in-frame splice site and lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (e) is shorter than isoform a.
    Source sequence(s)
    AK147272, AK147611, AL929153, BF464311
    Consensus CDS
    CCDS71170.1
    UniProtKB/Swiss-Prot
    Q9Z2H5
    UniProtKB/TrEMBL
    A2AUK7
    Related
    ENSMUSP00000105202.1, OTTMUSP00000016921, ENSMUST00000109574.7, OTTMUST00000037732
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:481511
    SAB; SAB domain
    pfam05902
    Location:592717
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  6. NM_013510.4NP_038538.1  band 4.1-like protein 1 isoform a

    See identical proteins and their annotated locations for NP_038538.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 3 and 4 all encode isoform a.
    Source sequence(s)
    AK147611, AL929153, BF464311
    Consensus CDS
    CCDS16966.1
    UniProtKB/Swiss-Prot
    Q9Z2H5
    UniProtKB/TrEMBL
    A2AUK5
    Related
    ENSMUSP00000099425.1, OTTMUSP00000016923, ENSMUST00000103136.7, OTTMUST00000037735
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:741866
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    156420878..156543214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011239275.2XP_011237577.1  band 4.1-like protein 1 isoform X5

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:492523
    SAB; SAB domain
    pfam05902
    Location:14511576
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  2. XM_006498711.3XP_006498774.1  band 4.1-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006498774.1

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14521577
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  3. XM_017315394.1XP_017170883.1  band 4.1-like protein 1 isoform X9

  4. XM_006498714.3XP_006498777.1  band 4.1-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006498777.1

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14521577
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  5. XM_006498713.3XP_006498776.1  band 4.1-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006498776.1

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14521577
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  6. XM_017315383.1XP_017170872.1  band 4.1-like protein 1 isoform X4

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14521577
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  7. XM_017315393.1XP_017170882.1  band 4.1-like protein 1 isoform X8

  8. XM_011239280.2XP_011237582.1  band 4.1-like protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011237582.1

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14521577
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  9. XM_006498708.3XP_006498771.1  band 4.1-like protein 1 isoform X1

    Conserved Domains (7) summary
    smart00295
    Location:111300
    B41; Band 4.1 homologues
    cd13184
    Location:295388
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:195300
    FERM_M; FERM central domain
    pfam04382
    Location:505536
    SAB; SAB domain
    pfam05902
    Location:14641589
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:397437
    FA; FERM adjacent (FA)
    pfam09379
    Location:113176
    FERM_N; FERM N-terminal domain
  10. XM_011239279.1XP_011237581.1  band 4.1-like protein 1 isoform X7

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:14671520
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  11. XM_011239281.1XP_011237583.1  band 4.1-like protein 1 isoform X10

    Related
    OTTMUSP00000017083, OTTMUST00000038096
    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:493524
    SAB; SAB domain
    pfam05902
    Location:605730
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  12. XM_011239277.1XP_011237579.1  band 4.1-like protein 1 isoform X3

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:482512
    SAB; SAB domain
    pfam05902
    Location:14401565
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  13. XM_011239276.1XP_011237578.1  band 4.1-like protein 1 isoform X2

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:485516
    SAB; SAB domain
    pfam05902
    Location:14441569
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain
  14. XM_011239278.1XP_011237580.1  band 4.1-like protein 1 isoform X6

    Conserved Domains (7) summary
    smart00295
    Location:99288
    B41; Band 4.1 homologues
    cd13184
    Location:283376
    FERM_C_4_1_family; FERM domain C-lobe of Protein 4.1 family
    pfam00373
    Location:183288
    FERM_M; FERM central domain
    pfam04382
    Location:474504
    SAB; SAB domain
    pfam05902
    Location:14321557
    4_1_CTD; 4.1 protein C-terminal domain (CTD)
    pfam08736
    Location:385425
    FA; FERM adjacent (FA)
    pfam09379
    Location:101164
    FERM_N; FERM N-terminal domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001003815.2: Suppressed sequence

    Description
    NM_001003815.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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