U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Eomes eomesodermin [ Mus musculus (house mouse) ]

Gene ID: 13813, updated on 17-Jan-2023

Summary

Official Symbol
Eomesprovided by MGI
Official Full Name
eomesoderminprovided by MGI
Primary source
MGI:MGI:1201683
See related
Ensembl:ENSMUSG00000032446 AllianceGenome:MGI:1201683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tbr2; TBR-2
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; RNA polymerase II-specific DNA-binding transcription factor binding activity; and chromatin binding activity. Involved in animal organ development and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including animal organ development; formation of primary germ layer; and trophectodermal cell differentiation. Located in chromatin and nucleus. Is expressed in several structures, including brain; early conceptus; eye; gonad; and limb. Orthologous to human EOMES (eomesodermin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 10.8), frontal lobe adult (RPKM 6.7) and 6 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Eomes in Genome Data Viewer
Location:
9 70.21 cM; 9 F3
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (118307254..118315200)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (118478186..118486132)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene pluripotency associated transcript 11 Neighboring gene predicted gene, 33285 Neighboring gene predicted gene, 33408 Neighboring gene predicted gene, 22479 Neighboring gene predicted gene, 33460 Neighboring gene golgi autoantigen, golgin subfamily a, 4 Neighboring gene family with sequence similarity 64, member A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in CD8-positive, alpha-beta T cell differentiation involved in immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA demethylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cardioblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation involved in embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cerebral cortex regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebral cortex regionalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in endodermal cell fate specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within endodermal cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in mesoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within mesoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesodermal to mesenchymal transition involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within trophectodermal cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within trophectodermal cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within type II interferon production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eomesodermin homolog
Names
T-box brain protein 2
T-brain-2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164789.2NP_001158261.1  eomesodermin homolog isoform 2

    See identical proteins and their annotated locations for NP_001158261.1

    Status: VALIDATED

    Source sequence(s)
    AC173340
    Consensus CDS
    CCDS52960.1
    UniProtKB/Swiss-Prot
    O54839
    Related
    ENSMUSP00000107393.2, ENSMUST00000111763.8
    Conserved Domains (2) summary
    cd00182
    Location:269462
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam16176
    Location:465686
    T-box_assoc; T-box transcription factor-associated
  2. NM_001411153.1NP_001398082.1  eomesodermin homolog isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC173340
  3. NM_010136.4NP_034266.2  eomesodermin homolog isoform 1

    See identical proteins and their annotated locations for NP_034266.2

    Status: VALIDATED

    Source sequence(s)
    AC173340
    Consensus CDS
    CCDS23603.1
    UniProtKB/Swiss-Prot
    O54839, Q9QYG7
    Related
    ENSMUSP00000035020.9, ENSMUST00000035020.15
    Conserved Domains (2) summary
    cd00182
    Location:269462
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
    pfam16176
    Location:484705
    T-box_assoc; T-box transcription factor-associated

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    118307254..118315200
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511940.4XP_006512003.1  eomesodermin homolog isoform X1

    Related
    ENSMUSP00000118079.2, ENSMUST00000150633.2
    Conserved Domains (1) summary
    pfam00907
    Location:271458
    T-box