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Eno2 enolase 2, gamma neuronal [ Mus musculus (house mouse) ]

Gene ID: 13807, updated on 2-Nov-2024

Summary

Official Symbol
Eno2provided by MGI
Official Full Name
enolase 2, gamma neuronalprovided by MGI
Primary source
MGI:MGI:95394
See related
Ensembl:ENSMUSG00000004267 AllianceGenome:MGI:95394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSE; Eno-2; D6Ertd375e
Summary
Predicted to enable enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Predicted to be involved in canonical glycolysis and gluconeogenesis. Located in cytoplasm; perikaryon; and photoreceptor inner segment. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to human ENO2 (enolase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 147.0), frontal lobe adult (RPKM 120.3) and 4 other tissues See more
Orthologs
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Genomic context

See Eno2 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124737018..124746489, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124760053..124769673, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8991 Neighboring gene U7 small nuclear RNA Neighboring gene atrophin 1 Neighboring gene STARR-seq mESC enhancer starr_17303 Neighboring gene leucine rich repeat containing 23 Neighboring gene predicted gene, 38895 Neighboring gene predicted gene, 38894

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (11) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphopyruvate hydratase activity IEA
Inferred from Electronic Annotation
more info
 
enables phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in canonical glycolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in glycolytic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
part_of phosphopyruvate hydratase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of phosphopyruvate hydratase complex IEA
Inferred from Electronic Annotation
more info
 
part_of phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
 
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
neural enolase
neuron-specific enolase
NP_001289571.1
NP_001342149.1
NP_001396615.1
NP_001396616.1
NP_001396617.1
NP_001396618.1
NP_001396619.1
NP_038537.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302642.2NP_001289571.1  gamma-enolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. Variants 2, 7, and 8 all encode the same isoform (2).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS80609.1
    UniProtKB/TrEMBL
    D3Z6E4, Q922A0
    Related
    ENSMUSP00000108095.2, ENSMUST00000112476.8
    Conserved Domains (1) summary
    PLN00191
    Location:2313
    PLN00191; enolase
  2. NM_001355220.2NP_001342149.1  gamma-enolase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3-6 all encode the same isoform (1).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS20527.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q3UJ20, Q545V3
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  3. NM_001409686.1NP_001396615.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
  4. NM_001409687.1NP_001396616.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
  5. NM_001409688.1NP_001396617.1  gamma-enolase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
  6. NM_001409689.1NP_001396618.1  gamma-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/TrEMBL
    D3Z6E4
  7. NM_001409690.1NP_001396619.1  gamma-enolase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164157
    UniProtKB/TrEMBL
    D3Z6E4
  8. NM_013509.4NP_038537.1  gamma-enolase isoform 1

    See identical proteins and their annotated locations for NP_038537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3-6 all encode the same isoform (1).
    Source sequence(s)
    AC164157
    Consensus CDS
    CCDS20527.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q3UJ20, Q545V3
    Related
    ENSMUSP00000004378.9, ENSMUST00000004378.15
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RNA

  1. NR_176885.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  2. NR_176886.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  3. NR_176887.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  4. NR_176888.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  5. NR_176889.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157
  6. NR_176890.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC164157

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124737018..124746489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)