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Eno2 enolase 2, gamma neuronal [ Mus musculus (house mouse) ]

Gene ID: 13807, updated on 8-Dec-2018

Summary

Official Symbol
Eno2provided by MGI
Official Full Name
enolase 2, gamma neuronalprovided by MGI
Primary source
MGI:MGI:95394
See related
Ensembl:ENSMUSG00000004267
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSE; Eno-2; AI837106; D6Ertd375e
Expression
Biased expression in cerebellum adult (RPKM 147.0), frontal lobe adult (RPKM 120.3) and 4 other tissues See more
Orthologs

Genomic context

See Eno2 in Genome Data Viewer
Location:
6 F2; 6 59.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (124760053..124769673, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (124710073..124719527, complement)

Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene U7 small nuclear RNA Neighboring gene atrophin 1 Neighboring gene leucine rich repeat containing 23 Neighboring gene predicted gene, 38895 Neighboring gene predicted gene, 38894

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphopyruvate hydratase activity ISO
Inferred from Sequence Orthology
more info
 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
glycolytic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell cortex region ISO
Inferred from Sequence Orthology
more info
 
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
membrane raft ISO
Inferred from Sequence Orthology
more info
 
myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
phosphopyruvate hydratase complex ISO
Inferred from Sequence Orthology
more info
 
photoreceptor inner segment IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synaptic membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
gamma-enolase
Names
2-phospho-D-glycerate hydro-lyase
neural enolase
neuron-specific enolase
NP_001289571.1
NP_038537.1
XP_006505566.1
XP_006505567.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302642.1NP_001289571.1  gamma-enolase isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the coding region compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC164157, BC031739, BC043708, BY282442, CA751156
    Consensus CDS
    CCDS80609.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    D3Z6E4
    Related
    ENSMUSP00000108095.1, ENSMUST00000112476.7
    Conserved Domains (2) summary
    PLN00191
    Location:2313
    PLN00191; enolase
    cd03313
    Location:5297
    enolase; Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions.
  2. NM_001355220.1NP_001342149.1  gamma-enolase isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC164157, BC043708
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  3. NM_013509.3NP_038537.1  gamma-enolase isoform 1

    See identical proteins and their annotated locations for NP_038537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1 and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC164157, AK131652, BC043708, BY282442
    Consensus CDS
    CCDS20527.1
    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
    Related
    ENSMUSP00000004378.8, ENSMUST00000004378.14
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

    Range
    124760053..124769673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505504.2XP_006505567.1  gamma-enolase isoform X1

    See identical proteins and their annotated locations for XP_006505567.1

    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
    Related
    ENSMUSP00000144861.1, ENSMUST00000204896.2
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
  2. XM_006505503.3XP_006505566.1  gamma-enolase isoform X1

    UniProtKB/Swiss-Prot
    P17183
    UniProtKB/TrEMBL
    Q545V3
    Conserved Domains (1) summary
    PLN00191
    Location:2432
    PLN00191; enolase
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