Format

Send to:

Choose Destination

RALYL RALY RNA binding protein like [ Homo sapiens (human) ]

Gene ID: 138046, updated on 13-Mar-2020

Summary

Official Symbol
RALYLprovided by HGNC
Official Full Name
RALY RNA binding protein likeprovided by HGNC
Primary source
HGNC:HGNC:27036
See related
Ensembl:ENSG00000184672 MIM:614648
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HNRPCL3
Expression
Biased expression in brain (RPKM 3.1), adrenal (RPKM 2.1) and 3 other tissues See more
Orthologs

Genomic context

See RALYL in Genome Data Viewer
Location:
8q21.2
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (84182765..84921844)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (85095453..85834079)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375932 Neighboring gene tropomyosin alpha-3 chain-like Neighboring gene tropomyosin 3 pseudogene 3 Neighboring gene RNA, U6 small nuclear 1040, pseudogene Neighboring gene PSMC2 pseudogene 2 Neighboring gene glucosamine-phosphate N-acetyltransferase 1 pseudogene Neighboring gene joining chain of multimeric IgA and IgM pseudogene 1 Neighboring gene ACTB pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
RNA-binding Raly-like protein
Names
heterogeneous nuclear ribonucleoprotein C-like 3
hnRNP core protein C-like 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100391.2NP_001093861.1  RNA-binding Raly-like protein isoform 1

    See identical proteins and their annotated locations for NP_001093861.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC012400, AF070623, BC031090, DN989439
    Consensus CDS
    CCDS55252.1
    UniProtKB/Swiss-Prot
    Q86SE5
    Related
    ENSP00000430128.1, ENST00000517638.5
    Conserved Domains (2) summary
    cd12605
    Location:33101
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:202258
    APG6; Autophagy protein Apg6
  2. NM_001100392.2NP_001093862.1  RNA-binding Raly-like protein isoform 2

    See identical proteins and their annotated locations for NP_001093862.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC012400, AK095560, BC031090, DA143105
    Consensus CDS
    CCDS55253.1
    UniProtKB/Swiss-Prot
    Q86SE5
    Related
    ENSP00000430394.1, ENST00000522455.5
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  3. NM_001100393.2NP_001093863.1  RNA-binding Raly-like protein isoform 2

    See identical proteins and their annotated locations for NP_001093863.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC012400, AK094543, AK095560, BC031090, DA143105
    Consensus CDS
    CCDS55253.1
    UniProtKB/Swiss-Prot
    Q86SE5
    Related
    ENSP00000428667.1, ENST00000521695.5
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  4. NM_001287243.2NP_001274172.1  RNA-binding Raly-like protein isoform 3

    See identical proteins and their annotated locations for NP_001274172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and the 5' coding region, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC012400, AK095026, AK123437, BC031090
    Consensus CDS
    CCDS75760.1
    UniProtKB/TrEMBL
    B3KT61
    Related
    ENSP00000430065.1, ENST00000518566.5
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  5. NM_001287244.1NP_001274173.1  RNA-binding Raly-like protein isoform 4

    See identical proteins and their annotated locations for NP_001274173.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon resulting in a novel 5' UTR and 5' coding region, compared to variant 1. It encodes isoform 4, which is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AK123437, BC031090
    Consensus CDS
    CCDS75761.1
    UniProtKB/Swiss-Prot
    Q86SE5
    Related
    ENSP00000428807.1, ENST00000523850.5
    Conserved Domains (1) summary
    pfam10779
    Location:126171
    XhlA; Haemolysin XhlA
  6. NM_001354305.1NP_001341234.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, AC103816, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  7. NM_001354306.1NP_001341235.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  8. NM_001354307.1NP_001341236.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  9. NM_001354308.1NP_001341237.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC027043, AC087368, AC092699, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  10. NM_001354309.1NP_001341238.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  11. NM_001354310.1NP_001341239.1  RNA-binding Raly-like protein isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC087368, BC031090
    Conserved Domains (1) summary
    pfam04111
    Location:101157
    APG6; Autophagy protein Apg6
  12. NM_001354311.1NP_001341240.1  RNA-binding Raly-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (1) summary
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  13. NM_001354312.1NP_001341241.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, AC103816, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  14. NM_001354313.1NP_001341242.1  RNA-binding Raly-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (1) summary
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  15. NM_001354314.1NP_001341243.1  RNA-binding Raly-like protein isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189244
    APG6; Autophagy protein Apg6
  16. NM_001354315.1NP_001341244.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  17. NM_001354316.1NP_001341245.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, AC103816, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  18. NM_001354317.1NP_001341246.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, AC103816, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  19. NM_001354318.1NP_001341247.1  RNA-binding Raly-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS75760.1
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  20. NM_001354319.1NP_001341248.1  RNA-binding Raly-like protein isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, AC103816, BC031090
    Conserved Domains (1) summary
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  21. NM_001354320.1NP_001341249.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  22. NM_001354321.1NP_001341250.1  RNA-binding Raly-like protein isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (3) summary
    COG0724
    Location:25203
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:33101
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:191247
    APG6; Autophagy protein Apg6
  23. NM_001354322.1NP_001341251.1  RNA-binding Raly-like protein isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (2) summary
    COG0724
    Location:25203
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:33101
    RRM_SF; RNA recognition motif (RRM) superfamily
  24. NM_001354323.1NP_001341252.1  RNA-binding Raly-like protein isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Conserved Domains (1) summary
    cl17169
    Location:33101
    RRM_SF; RNA recognition motif (RRM) superfamily
  25. NM_001354325.1NP_001341254.1  RNA-binding Raly-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368, BC031090
    Consensus CDS
    CCDS55253.1
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6
  26. NM_173848.7NP_776247.3  RNA-binding Raly-like protein isoform 2

    See identical proteins and their annotated locations for NP_776247.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 through 4 encode the same isoform (2), which has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC009901, AC012400, AC027043, AC087368
    Consensus CDS
    CCDS55253.1
    UniProtKB/Swiss-Prot
    Q86SE5
    Related
    ENSP00000430367.1, ENST00000521268.6
    Conserved Domains (2) summary
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:189245
    APG6; Autophagy protein Apg6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    84182765..84921844
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447066.1XP_024302834.1  RNA-binding Raly-like protein isoform X1

    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  2. XM_017013071.1XP_016868560.1  RNA-binding Raly-like protein isoform X1

    UniProtKB/TrEMBL
    B3KT61
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  3. XM_017013080.2XP_016868569.1  RNA-binding Raly-like protein isoform X3

    Conserved Domains (2) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. XM_017013081.2XP_016868570.1  RNA-binding Raly-like protein isoform X4

    Conserved Domains (2) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  5. XM_024447070.1XP_024302838.1  RNA-binding Raly-like protein isoform X7

    Conserved Domains (1) summary
    pfam04111
    Location:90146
    APG6; Autophagy protein Apg6
  6. XM_011517462.3XP_011515764.1  RNA-binding Raly-like protein isoform X3

    Conserved Domains (2) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  7. XM_017013082.1XP_016868571.1  RNA-binding Raly-like protein isoform X4

    Conserved Domains (2) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cl17169
    Location:2088
    RRM_SF; RNA recognition motif (RRM) superfamily
  8. XM_017013068.1XP_016868557.1  RNA-binding Raly-like protein isoform X1

    UniProtKB/TrEMBL
    B3KT61
    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  9. XM_024447067.1XP_024302835.1  RNA-binding Raly-like protein isoform X1

    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  10. XM_024447068.1XP_024302836.1  RNA-binding Raly-like protein isoform X2

    Conserved Domains (2) summary
    COG0724
    Location:25203
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:33101
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
  11. XM_024447069.1XP_024302837.1  RNA-binding Raly-like protein isoform X6

    Conserved Domains (1) summary
    pfam04111
    Location:98154
    APG6; Autophagy protein Apg6
  12. XM_024447065.1XP_024302833.1  RNA-binding Raly-like protein isoform X1

    Conserved Domains (3) summary
    COG0724
    Location:12190
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12605
    Location:2088
    RRM_RALYL; RNA recognition motif in vertebrate RNA-binding Raly-like protein (RALYL)
    pfam04111
    Location:178234
    APG6; Autophagy protein Apg6
  13. XM_017013084.2XP_016868573.1  RNA-binding Raly-like protein isoform X5

Support Center