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Enah ENAH actin regulator [ Mus musculus (house mouse) ]

Gene ID: 13800, updated on 8-Jan-2023

Summary

Official Symbol
Enahprovided by MGI
Official Full Name
ENAH actin regulatorprovided by MGI
Primary source
MGI:MGI:108360
See related
Ensembl:ENSMUSG00000022995 AllianceGenome:MGI:108360
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mena; WBP8; Ndpp1; NDPP-1
Summary
Enables SH3 domain binding activity and profilin binding activity. Involved in actin filament organization and actin polymerization-dependent cell motility. Acts upstream of or within actin polymerization or depolymerization; cellular response to leukemia inhibitory factor; and nervous system development. Located in several cellular components, including focal adhesion; lamellipodium; and stress fiber. Is expressed in several structures, including branchial arch; early embryo; gonad; limb bud; and nervous system. Orthologous to human ENAH (ENAH actin regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.7), CNS E14 (RPKM 9.8) and 19 other tissues See more
Orthologs
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Genomic context

See Enah in Genome Data Viewer
Location:
1 H5; 1 84.93 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (181723949..181848132, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (181896384..182027556, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene lamin B receptor Neighboring gene predicted gene, 33669 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene predicted gene, 38648 Neighboring gene nuclear encoded tRNA serine 1 (anticodon GCT)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SH3 domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables profilin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables profilin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in actin filament organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within actin polymerization or depolymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in actin polymerization-dependent cell motility IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in actin polymerization-dependent cell motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein enabled homolog
Names
NPC derived proline rich protein 1
enabled homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083120.2NP_001076589.1  protein enabled homolog isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS48473.1
    UniProtKB/TrEMBL
    A0A0A6YW06
    Related
    ENSMUSP00000141344.2, ENSMUST00000195059.6
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:748781
    VASP_tetra; VASP tetramerization domain
  2. NM_001083121.2NP_001076590.1  protein enabled homolog isoform 4

    See identical proteins and their annotated locations for NP_001076590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 5' coding region and uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded protein (isoform 4) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS78764.1
    UniProtKB/Swiss-Prot
    Q03173
    Related
    ENSMUSP00000141462.2, ENSMUST00000193703.6
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:504537
    VASP_tetra; VASP tetramerization domain
  3. NM_008680.3NP_032706.2  protein enabled homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and contains an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS48474.1
    UniProtKB/TrEMBL
    E9QKQ9
    Related
    ENSMUSP00000106659.4, ENSMUST00000111030.6
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:752785
    VASP_tetra; VASP tetramerization domain
  4. NM_010135.3NP_034265.2  protein enabled homolog isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC122204, AC165229
    Consensus CDS
    CCDS35811.1
    UniProtKB/TrEMBL
    E9QLZ9
    Related
    ENSMUSP00000077781.7, ENSMUST00000078719.13
    Conserved Domains (2) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:767800
    VASP_tetra; VASP tetramerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    181723949..181848132 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159237.1XP_036015130.1  protein enabled homolog isoform X19

    UniProtKB/TrEMBL
    E9QKR1
    Related
    ENSMUSP00000106653.5, ENSMUST00000111024.10
    Conserved Domains (3) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:525559
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:356382
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  2. XM_006496652.4XP_006496715.1  protein enabled homolog isoform X20

    Related
    ENSMUSP00000141936.2, ENSMUST00000193074.6
    Conserved Domains (2) summary
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:498532
    VASP_tetra; VASP tetramerisation domain
  3. XM_006496651.5XP_006496714.1  protein enabled homolog isoform X18

    Conserved Domains (2) summary
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:535569
    VASP_tetra; VASP tetramerisation domain
  4. XM_006496650.4XP_006496713.1  protein enabled homolog isoform X15

    Conserved Domains (2) summary
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:556590
    VASP_tetra; VASP tetramerisation domain
  5. XM_006496646.5XP_006496709.1  protein enabled homolog isoform X8

    Conserved Domains (3) summary
    PHA03247
    Location:333553
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:779813
    VASP_tetra; VASP tetramerisation domain
  6. XM_030247170.2XP_030103030.1  protein enabled homolog isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:333553
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:800834
    VASP_tetra; VASP tetramerisation domain
  7. XM_030247143.2XP_030103003.1  protein enabled homolog isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:352572
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:819853
    VASP_tetra; VASP tetramerisation domain
  8. XM_030247134.2XP_030102994.1  protein enabled homolog isoform X1

    Conserved Domains (3) summary
    PHA03247
    Location:356576
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:823857
    VASP_tetra; VASP tetramerisation domain
  9. XM_030247158.2XP_030103018.1  protein enabled homolog isoform X3

    Conserved Domains (3) summary
    PHA03247
    Location:337557
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:804838
    VASP_tetra; VASP tetramerisation domain
  10. XM_006496645.5XP_006496708.1  protein enabled homolog isoform X7

    Conserved Domains (3) summary
    PHA03247
    Location:337557
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:783817
    VASP_tetra; VASP tetramerisation domain
  11. XM_036159112.1XP_036015005.1  protein enabled homolog isoform X13

    Conserved Domains (3) summary
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:575609
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:406432
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  12. XM_006496643.5XP_006496706.1  protein enabled homolog isoform X5

    Conserved Domains (3) summary
    PHA03247
    Location:352572
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:798832
    VASP_tetra; VASP tetramerisation domain
  13. XM_036159177.1XP_036015070.1  protein enabled homolog isoform X16

    Conserved Domains (3) summary
    cd01207
    Location:36143
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:554588
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:406432
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  14. XM_006496648.4XP_006496711.1  protein enabled homolog isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:231451
    PHA03247; large tegument protein UL36; Provisional
    pfam08776
    Location:698732
    VASP_tetra; VASP tetramerisation domain
  15. XM_006496649.5XP_006496712.1  protein enabled homolog isoform X12

    Conserved Domains (2) summary
    PHA03247
    Location:227447
    PHA03247; large tegument protein UL36; Provisional
    pfam08776
    Location:694728
    VASP_tetra; VASP tetramerisation domain
  16. XM_036159132.1XP_036015025.1  protein enabled homolog isoform X14

    Conserved Domains (3) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:568602
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:420446
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  17. XM_006496647.5XP_006496710.1  protein enabled homolog isoform X10

    Related
    ENSMUSP00000136863.2, ENSMUST00000177811.8
    Conserved Domains (3) summary
    PHA03247
    Location:302522
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:769803
    VASP_tetra; VASP tetramerisation domain
  18. XM_036159054.1XP_036014947.1  protein enabled homolog isoform X9

    Conserved Domains (4) summary
    PHA03247
    Location:306526
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:773807
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:604630
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  19. XM_036159202.1XP_036015095.1  protein enabled homolog isoform X17

    Conserved Domains (3) summary
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:544578
    VASP_tetra; VASP tetramerisation domain
    cd22185
    Location:375401
    WH2_hVASP-like; Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) of human Vasodilator-stimulated phosphoprotein and related proteins
  20. XM_006496644.5XP_006496707.1  protein enabled homolog isoform X6

    Conserved Domains (3) summary
    PHA03247
    Location:325545
    PHA03247; large tegument protein UL36; Provisional
    cd01207
    Location:5112
    EVH1_Ena_VASP-like; Enabled/VASP family EVH1 domain
    pfam08776
    Location:792826
    VASP_tetra; VASP tetramerisation domain

RNA

  1. XR_001780490.3 RNA Sequence