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En1 engrailed 1 [ Mus musculus (house mouse) ]

Gene ID: 13798, updated on 18-Apr-2024

Summary

Official Symbol
En1provided by MGI
Official Full Name
engrailed 1provided by MGI
Primary source
MGI:MGI:95389
See related
Ensembl:ENSMUSG00000058665 AllianceGenome:MGI:95389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
En-1; Mo-en.1; engrailed-1
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; drinking behavior; and motor learning. Acts upstream of or within several processes, including embryonic forelimb morphogenesis; nervous system development; and regionalization. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; limb; and limb primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human EN1 (engrailed homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 5.5), whole brain E14.5 (RPKM 3.8) and 5 other tissues See more
Orthologs
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Genomic context

Location:
1 E2.3; 1 52.74 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (120530246..120535719)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (120602487..120607991)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02059 Neighboring gene macrophage receptor with collagenous structure Neighboring gene STARR-seq mESC enhancer starr_02060 Neighboring gene STARR-seq mESC enhancer starr_02061 Neighboring gene STARR-seq mESC enhancer starr_02062 Neighboring gene STARR-seq mESC enhancer starr_02064 Neighboring gene predicted gene, 41939 Neighboring gene RIKEN cDNA 2610027F03 gene Neighboring gene predicted gene, 34352 Neighboring gene STARR-seq mESC enhancer starr_02065 Neighboring gene STARR-seq mESC enhancer starr_02066 Neighboring gene STARR-seq mESC enhancer starr_02068 Neighboring gene STARR-seq mESC enhancer starr_02069 Neighboring gene predicted gene 29345

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cerebellum development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron differentiation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic forelimb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hindbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within midbrain-hindbrain boundary development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
homeobox protein engrailed-1
Names
homeobox protein en-1
mo-En-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010133.3NP_034263.2  homeobox protein engrailed-1

    See identical proteins and their annotated locations for NP_034263.2

    Status: VALIDATED

    Source sequence(s)
    AC133286
    Consensus CDS
    CCDS15235.1
    UniProtKB/Swiss-Prot
    P09065, Q3USF7
    Related
    ENSMUSP00000078659.8, ENSMUST00000079721.9
    Conserved Domains (2) summary
    pfam00046
    Location:315368
    Homeobox; Homeobox domain
    pfam10525
    Location:370399
    Engrail_1_C_sig; Engrailed homeobox C-terminal signature domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    120530246..120535719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)