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UBXN2B UBX domain protein 2B [ Homo sapiens (human) ]

Gene ID: 137886, updated on 5-Aug-2018

Summary

Official Symbol
UBXN2Bprovided by HGNC
Official Full Name
UBX domain protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:27035
See related
Ensembl:ENSG00000215114 MIM:610686; Vega:OTTHUMG00000164300
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p37
Expression
Ubiquitous expression in brain (RPKM 9.6), thyroid (RPKM 8.2) and 25 other tissues See more
Orthologs

Genomic context

See UBXN2B in Genome Data Viewer
Location:
8q12.1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (58411264..58451508)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (59323823..59364060)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986945 Neighboring gene VISTA enhancer hs1364 Neighboring gene uncharacterized LOC101929528 Neighboring gene protein tyrosine phosphatase, non-receptor type 11 pseudogene Neighboring gene CYP7A1 5' regulatory region Neighboring gene peptidylprolyl isomerase A pseudogene Neighboring gene cytochrome P450 family 7 subfamily A member 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
PubMed 
membrane fusion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of protein localization to centrosome IGI
Inferred from Genetic Interaction
more info
PubMed 
nuclear envelope reassembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of mitotic centrosome separation IGI
Inferred from Genetic Interaction
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
spindle pole centrosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
UBX domain-containing protein 2B
Names
NSFL1 cofactor p37
p97 cofactor p37

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077619.1NP_001071087.1  UBX domain-containing protein 2B isoform 1

    See identical proteins and their annotated locations for NP_001071087.1

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, U79282
    Consensus CDS
    CCDS43741.1
    UniProtKB/Swiss-Prot
    Q14CS0
    Related
    ENSP00000382507.2, OTTHUMP00000226407, ENST00000399598.6, OTTHUMT00000378184
    Conserved Domains (2) summary
    cd01770
    Location:253331
    p47_UBX; p47-like ubiquitin domain
    smart00553
    Location:140232
    SEP; Domain present in Saccharomyces cerevisiae Shp1, Drosophila melanogaster eyes closed gene (eyc), and vertebrate p47
  2. NM_001330535.1NP_001317464.1  UBX domain-containing protein 2B isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC113645, BE502216, DA185219, DA242203
    Consensus CDS
    CCDS83297.1
    UniProtKB/Swiss-Prot
    Q14CS0
    UniProtKB/TrEMBL
    E5RJ36
    Related
    ENSP00000492780.1, ENST00000638450.1
    Conserved Domains (1) summary
    cl02662
    Location:146178
    SEP; SEP domain
  3. NM_001363181.1NP_001350110.1  UBX domain-containing protein 2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, U79282
    Conserved Domains (2) summary
    cd01770
    Location:207285
    p47_UBX; p47-like ubiquitin domain
    cl02662
    Location:146182
    SEP; SEP domain

RNA

  1. NR_156456.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK126300, BC113645, DB337840, U79282

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    58411264..58451508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251165.2XP_005251222.1  UBX domain-containing protein 2B isoform X1

    Conserved Domains (2) summary
    cd01770
    Location:207285
    p47_UBX; p47-like ubiquitin domain
    cl02662
    Location:146182
    SEP; SEP domain

RNA

  1. XR_242453.2 RNA Sequence

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