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ABRA actin binding Rho activating protein [ Homo sapiens (human) ]

Gene ID: 137735, updated on 22-May-2022

Summary

Official Symbol
ABRAprovided by HGNC
Official Full Name
actin binding Rho activating proteinprovided by HGNC
Primary source
HGNC:HGNC:30655
See related
Ensembl:ENSG00000174429 MIM:609747; AllianceGenome:HGNC:30655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STARS
Summary
Predicted to enable actin binding activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity; positive regulation of Rho protein signal transduction; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of transcription, DNA-templated and protein import into nucleus. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart (RPKM 6.8), esophagus (RPKM 1.8) and 2 other tissues See more
Orthologs
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Genomic context

See ABRA in Genome Data Viewer
Location:
8q23.1
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (106759483..106770244, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (107887295..107898048, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (107771711..107782472, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene oxidation resistance 1 Neighboring gene transgelin 2 pseudogene 1 Neighboring gene RNA, U7 small nuclear 84 pseudogene Neighboring gene uncharacterized LOC124902004 Neighboring gene uncharacterized LOC124902066

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
is_active_in sarcomere IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in sarcomere ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
actin-binding Rho-activating protein
Names
striated muscle activator of Rho-dependent signaling

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139166.5NP_631905.1  actin-binding Rho-activating protein

    See identical proteins and their annotated locations for NP_631905.1

    Status: VALIDATED

    Source sequence(s)
    AL832152, BC105103
    Consensus CDS
    CCDS6305.1
    UniProtKB/Swiss-Prot
    Q8N0Z2
    Related
    ENSP00000311436.3, ENST00000311955.4
    Conserved Domains (1) summary
    pfam14705
    Location:305379
    Costars; Costars

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    106759483..106770244 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    107887295..107898048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)