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Adgre1 adhesion G protein-coupled receptor E1 [ Mus musculus (house mouse) ]

Gene ID: 13733, updated on 11-Dec-2018

Summary

Official Symbol
Adgre1provided by MGI
Official Full Name
adhesion G protein-coupled receptor E1provided by MGI
Primary source
MGI:MGI:106912
See related
Ensembl:ENSMUSG00000004730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Emr1; Ly71; F4/80; Gpf480; TM7LN3; DD7A5-7; EGF-TM7
Expression
Broad expression in spleen adult (RPKM 13.7), mammary gland adult (RPKM 11.5) and 27 other tissues See more
Orthologs

Genomic context

See Adgre1 in Genome Data Viewer
Location:
17 D; 17 29.8 cM
Exon count:
23
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (57358651..57483529)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (57498109..57622952)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3A pseudogene Neighboring gene vav 1 oncogene Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene heat shock protein 8 pseudogene Neighboring gene vomeronasal 2, receptor 120 Neighboring gene predicted gene, 18139

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (4) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune system process IEA
Inferred from Electronic Annotation
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
adhesion G protein-coupled receptor E1
Names
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
cell surface glycoprotein F4/80

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355722.1NP_001342651.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    BC075688, BY197649, BY493080
    Conserved Domains (4) summary
    smart00303
    Location:591640
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:644906
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  2. NM_001355723.1NP_001342652.1  adhesion G protein-coupled receptor E1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK155862, BC075688, BY197649, BY493080
    Conserved Domains (5) summary
    smart00303
    Location:575624
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:117156
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:206242
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam16489
    Location:420549
    GAIN; GPCR-Autoproteolysis INducing (GAIN) domain
    cd15439
    Location:628890
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  3. NM_010130.4NP_034260.1  adhesion G protein-coupled receptor E1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034260.1

    Status: VALIDATED

    Source sequence(s)
    AK133202, BY197649, BY493080
    Consensus CDS
    CCDS50160.1
    UniProtKB/Swiss-Prot
    Q61549
    UniProtKB/TrEMBL
    Q3U9R0
    Related
    ENSMUSP00000083971.5, ENSMUST00000086763.12
    Conserved Domains (4) summary
    smart00303
    Location:591640
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:644906
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    57358651..57483529
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523601.1XP_006523664.1  adhesion G protein-coupled receptor E1 isoform X1

    UniProtKB/Swiss-Prot
    Q61549
    UniProtKB/TrEMBL
    Q3U9R0
    Related
    ENSMUSP00000004850.7, ENSMUST00000004850.7
    Conserved Domains (4) summary
    smart00303
    Location:591640
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:222258
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd15439
    Location:644906
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
  2. XM_006523602.1XP_006523665.1  adhesion G protein-coupled receptor E1 isoform X2

    Conserved Domains (4) summary
    smart00303
    Location:450499
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:3262
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:81117
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:504744
    7tm_2; 7 transmembrane receptor (Secretin family)
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