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Aimp1 aminoacyl tRNA synthetase complex-interacting multifunctional protein 1 [ Mus musculus (house mouse) ]

Gene ID: 13722, updated on 8-Jan-2023

Summary

Official Symbol
Aimp1provided by MGI
Official Full Name
aminoacyl tRNA synthetase complex-interacting multifunctional protein 1provided by MGI
Primary source
MGI:MGI:102774
See related
Ensembl:ENSMUSG00000028029 AllianceGenome:MGI:102774
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p43; Emap2; Scye1; EMAPII; AIMP1/p43; 9830137A06Rik
Summary
Enables cytokine activity. Involved in leukocyte migration and positive regulation of glucagon secretion. Located in extracellular space. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 3. Orthologous to human AIMP1 (aminoacyl tRNA synthetase complex interacting multifunctional protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 32.1), placenta adult (RPKM 29.4) and 24 other tissues See more
Orthologs
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Genomic context

See Aimp1 in Genome Data Viewer
Location:
3; 3 G3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (132366259..132390151, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (132660498..132684390, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene GIMAP family P-loop NTPase domain containing 1 Neighboring gene predicted gene 9402 Neighboring gene TBC1 domain containing kinase Neighboring gene predicted gene, 30294 Neighboring gene predicted gene, 22322

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables tRNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in leukocyte migration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of glucagon secretion IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
aminoacyl tRNA synthase complex-interacting multifunctional protein 1
Names
ARS inducible multifunctional protein 1
endothelial monocyte activating polypeptide 2
multisynthase complex auxiliary component p43
multisynthetase complex auxiliary component p43
small inducible cytokine subfamily E, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368626.1NP_001355555.1  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC135118
    Consensus CDS
    CCDS89689.1
    UniProtKB/Swiss-Prot
    Q60659
    Related
    ENSMUSP00000142513.3, ENSMUST00000198513.6
  2. NM_007926.2NP_031952.2  aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform 1

    See identical proteins and their annotated locations for NP_031952.2

    Status: VALIDATED

    Source sequence(s)
    AK133859, BY256548, BY631162
    Consensus CDS
    CCDS38642.1
    UniProtKB/TrEMBL
    Q3UZG4
    Related
    ENSMUSP00000029663.7, ENSMUST00000029663.11
    Conserved Domains (2) summary
    cd02799
    Location:157259
    tRNA_bind_EMAP-II_like; tRNA-binding-domain-containing EMAP2-like proteins. This family contains a diverse fraction of tRNA binding proteins, including Caenorhabditis elegans methionyl-tRNA synthetase (CeMetRS), human tyrosyl- tRNA synthetase (hTyrRS), Saccharomyces cerevisiae ...
    pfam04880
    Location:17117
    NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    132366259..132390151 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)