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CPN2 carboxypeptidase N subunit 2 [ Homo sapiens (human) ]

Gene ID: 1370, updated on 21-Dec-2019

Summary

Official Symbol
CPN2provided by HGNC
Official Full Name
carboxypeptidase N subunit 2provided by HGNC
Primary source
HGNC:HGNC:2313
See related
Ensembl:ENSG00000178772 MIM:603104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ACBP
Expression
Restricted expression toward liver (RPKM 60.4) See more
Orthologs

Genomic context

See CPN2 in Genome Data Viewer
Location:
3q29
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (194339765..194351387, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194060494..194072063, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2048 Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene leucine rich repeat containing 15 Neighboring gene glycoprotein V platelet

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of carboxypeptidase N, polypeptide 2 (CPN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
protein stabilization NAS
Non-traceable Author Statement
more info
PubMed 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
extracellular exosome HDA PubMed 
extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
carboxypeptidase N subunit 2
Names
arginine carboxypeptidase
carboxypeptidase N 83 kDa chain
carboxypeptidase N large subunit
carboxypeptidase N regulatory subunit
carboxypeptidase N, polypeptide 2, 83kD
NP_001073982.3
NP_001278917.1
XP_005269337.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080513.4NP_001073982.3  carboxypeptidase N subunit 2 precursor

    See identical proteins and their annotated locations for NP_001073982.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC174158
    Consensus CDS
    CCDS33920.1
    UniProtKB/Swiss-Prot
    P22792
    Related
    ENSP00000319464.3, ENST00000323830.4
    Conserved Domains (6) summary
    smart00013
    Location:2153
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294349
    LRR_8; Leucine rich repeat
  2. NM_001291988.2NP_001278917.1  carboxypeptidase N subunit 2 precursor

    See identical proteins and their annotated locations for NP_001278917.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Variants 1 and 3 encode the same protein.
    Source sequence(s)
    AC174158
    Consensus CDS
    CCDS33920.1
    UniProtKB/Swiss-Prot
    P22792
    Related
    ENSP00000402232.1, ENST00000429275.1
    Conserved Domains (6) summary
    smart00013
    Location:2153
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294349
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    194339765..194351387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269280.4XP_005269337.1  carboxypeptidase N subunit 2 isoform X1

    See identical proteins and their annotated locations for XP_005269337.1

    UniProtKB/Swiss-Prot
    P22792
    Conserved Domains (6) summary
    smart00013
    Location:2153
    LRRNT; Leucine rich repeat N-terminal domain
    smart00082
    Location:395446
    LRRCT; Leucine rich repeat C-terminal domain
    cd00116
    Location:149356
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:387399
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:123146
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:294349
    LRR_8; Leucine rich repeat

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001309.1: Suppressed sequence

    Description
    NM_001309.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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