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Eif4g2 eukaryotic translation initiation factor 4, gamma 2 [ Mus musculus (house mouse) ]

Gene ID: 13690, updated on 8-Jan-2023

Summary

Official Symbol
Eif4g2provided by MGI
Official Full Name
eukaryotic translation initiation factor 4, gamma 2provided by MGI
Primary source
MGI:MGI:109207
See related
Ensembl:ENSMUSG00000005610 AllianceGenome:MGI:109207
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p97; Nat1; DAP-5; Natm1; E130105L11Rik
Summary
Translation initiation is mediated by specific recognition of the cap structure by eukaryotic translation initiation factor 4F (eIF4F), which is a cap binding protein complex that consists of three subunits: eIF4A, eIF4E and eIF4G. The protein encoded by this gene shares similarity with the C-terminal region of eIF4G, that contains the binding sites for eIF4A and eIF3; eIF4G in addition, contains a binding site for eIF4E at the N-terminus. Unlike eIF4G which supports cap-dependent and independent translation, this gene product functions as a general repressor of translation by forming translationally inactive complexes. Transgene expression of the apolipoprotein B mRNA-editing enzyme (APOBEC-1) causes extensive editing of this mRNA, which could contribute to the potent oncogenesis induced by overexpression of APOBEC-1. In vitro and in vivo studies in human indicate that translation of this mRNA initiates exclusively at a non-AUG (GUG) codon. This also appears to be true for mouse. Two alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 106.9), CNS E14 (RPKM 96.1) and 24 other tissues See more
Orthologs
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Genomic context

See Eif4g2 in Genome Data Viewer
Location:
7 E3; 7 58.0 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (110667192..110682237, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (111067985..111083030, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol 1,4,5-triphosphate receptor associated 1 Neighboring gene predicted gene 16336 Neighboring gene CTR9 homolog, Paf1/RNA polymerase II complex component Neighboring gene predicted gene, 23262 Neighboring gene zinc finger, BED type containing 5, pseudogene Neighboring gene predicted gene, 33098

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation factor activity, RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 4 gamma 2
Names
eIF-4-gamma 2
eIF-4G 2
eIF4G 2
novel APOBEC-1 target 1
translation repressor Nat1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040131.2NP_001035221.1  eukaryotic translation initiation factor 4 gamma 2 isoform 2

    See identical proteins and their annotated locations for NP_001035221.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AC150312, AC159206, AI874618, BC043034
    Consensus CDS
    CCDS40087.1
    UniProtKB/Swiss-Prot
    Q62448
    Related
    ENSMUSP00000125375.2, ENSMUST00000161051.8
    Conserved Domains (4) summary
    cd11559
    Location:701837
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:505618
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain
    pfam11235
    Location:412509
    Med25_SD1; Mediator complex subunit 25 synapsin 1
  2. NM_013507.3NP_038535.2  eukaryotic translation initiation factor 4 gamma 2 isoform 1

    See identical proteins and their annotated locations for NP_038535.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AC150312, AI874618, BC043034
    Consensus CDS
    CCDS40088.1
    UniProtKB/Swiss-Prot
    Q62448
    UniProtKB/TrEMBL
    A0JNY7
    Related
    ENSMUSP00000124551.2, ENSMUST00000162415.9
    Conserved Domains (3) summary
    cd11559
    Location:739875
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    smart00544
    Location:543656
    MA3; Domain in DAP-5, eIF4G, MA-3 and other proteins
    pfam02854
    Location:78308
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    110667192..110682237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)