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Eif4e eukaryotic translation initiation factor 4E [ Mus musculus (house mouse) ]

Gene ID: 13684, updated on 8-Feb-2024

Summary

Official Symbol
Eif4eprovided by MGI
Official Full Name
eukaryotic translation initiation factor 4Eprovided by MGI
Primary source
MGI:MGI:95305
See related
Ensembl:ENSMUSG00000028156 AllianceGenome:MGI:95305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
If4e; eIF-4E; EG668879; Eif4e-ps
Summary
This gene encodes a component of the eukaryotic translation initiation factor 4F complex, which recognizes the 7-methylguanosine cap structure at the 5' end of messenger RNAs. The encoded protein aids in translation initiation by recruiting ribosomes to the 5'-cap structure. Association of this protein with the 4F complex is the rate-limiting step in translation initiation. This gene acts as a proto-oncogene, and its expression and activation is associated with transformation and tumorigenesis. It has also been associated with autism spectrum disorders. Consistently, knockout of this gene results in increased translation of neuroligins, postsynaptic proteins linked to autism spectrum disorders. Pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E18 (RPKM 11.1), CNS E11.5 (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

See Eif4e in Genome Data Viewer
Location:
3 G3; 3 64.3 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (138231952..138265457)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (138526191..138559696)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_09108 Neighboring gene STARR-positive B cell enhancer ABC_E6139 Neighboring gene alcohol dehydrogenase 5 (class III), chi polypeptide Neighboring gene methionyl aminopeptidase 1 Neighboring gene predicted gene, 32553 Neighboring gene STARR-positive B cell enhancer ABC_E1269 Neighboring gene microRNA 1956 Neighboring gene STARR-seq mESC enhancer starr_09110 Neighboring gene predicted gene, 29762 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1)  1 citation
  • Gene trapped (1) 
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC103177

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA 7-methylguanosine cap binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables eukaryotic initiation factor 4G binding ISO
Inferred from Sequence Orthology
more info
 
enables mRNA cap binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within behavioral fear response IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cellular response to dexamethasone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mRNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mRNA transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nuclear export IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of translation at postsynapse, modulating synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in P-body ISO
Inferred from Sequence Orthology
more info
 
part_of RISC complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatoid body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic translation initiation factor 4F complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 4F complex ISO
Inferred from Sequence Orthology
more info
 
part_of eukaryotic translation initiation factor 4F complex NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 4E
Names
eIF-4F 25 kDa subunit
mRNA cap-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313980.1NP_001300909.1  eukaryotic translation initiation factor 4E isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and contains an alternate exon in the 5' coding region that results in use of a downstream start codon compared to variant 1. It encodes isoform 2, which has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC113988, AK167097, BP770650
    Consensus CDS
    CCDS84679.1
    UniProtKB/TrEMBL
    A0A0G2JFB4
    Related
    ENSMUSP00000143104.2, ENSMUST00000196990.5
    Conserved Domains (1) summary
    pfam01652
    Location:2112
    IF4E; Eukaryotic initiation factor 4E
  2. NM_007917.4NP_031943.3  eukaryotic translation initiation factor 4E isoform 1

    See identical proteins and their annotated locations for NP_031943.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC113988, AK082867, AK167097, BP770650, CN714483
    Consensus CDS
    CCDS38654.1
    UniProtKB/Swiss-Prot
    P20415, P63073
    UniProtKB/TrEMBL
    Q3TK95, Q8C470
    Related
    ENSMUSP00000029803.8, ENSMUST00000029803.12
    Conserved Domains (1) summary
    pfam01652
    Location:38197
    IF4E; Eukaryotic initiation factor 4E

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    138231952..138265457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500993.4XP_006501056.1  eukaryotic translation initiation factor 4E isoform X1

    UniProtKB/TrEMBL
    Q8C470
    Conserved Domains (1) summary
    pfam01652
    Location:51210
    IF4E; Eukaryotic initiation factor 4E
  2. XM_036162887.1XP_036018780.1  eukaryotic translation initiation factor 4E isoform X2

    UniProtKB/Swiss-Prot
    P20415, P63073
    UniProtKB/TrEMBL
    Q3TK95, Q8C470
    Related
    ENSMUSP00000143690.2, ENSMUST00000200020.5
    Conserved Domains (1) summary
    pfam01652
    Location:38197
    IF4E; Eukaryotic initiation factor 4E
  3. XM_017319453.3XP_017174942.1  eukaryotic translation initiation factor 4E isoform X3

    UniProtKB/TrEMBL
    A0A0G2JFB4
    Conserved Domains (1) summary
    pfam01652
    Location:2112
    IF4E; Eukaryotic initiation factor 4E