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Ei24 etoposide induced 2.4 mRNA [ Mus musculus (house mouse) ]

Gene ID: 13663, updated on 26-Sep-2022

Summary

Official Symbol
Ei24provided by MGI
Official Full Name
etoposide induced 2.4 mRNAprovided by MGI
Primary source
MGI:MGI:108090
See related
Ensembl:ENSMUSG00000062762 AllianceGenome:MGI:108090
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PIG8
Summary
Predicted to enable importin-alpha family protein binding activity. Acts upstream of or within several processes, including cellular response to UV-C; intrinsic apoptotic signaling pathway in response to DNA damage; and negative regulation of protein import into nucleus. Predicted to be located in Golgi apparatus and cytosol. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human EI24 (EI24 autophagy associated transmembrane protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver adult (RPKM 47.4), bladder adult (RPKM 40.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ei24 in Genome Data Viewer
Location:
9 A4; 9 20.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (36690449..36708630, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (36779153..36797334, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene checkpoint kinase 1 Neighboring gene STT3, subunit of the oligosaccharyltransferase complex, homolog A (S. cerevisiae) Neighboring gene predicted gene, 26787 Neighboring gene predicted gene 27219 Neighboring gene fasciculation and elongation protein zeta 1 (zygin I) Neighboring gene Pbx/knotted 1 homeobox 2 Neighboring gene predicted gene, 34652

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables importin-alpha family protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
etoposide-induced protein 2.4
Names
p53-induced gene 8 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199494.2NP_001186423.2  etoposide-induced protein 2.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC155921
    Consensus CDS
    CCDS22973.2
    UniProtKB/Swiss-Prot
    Q3UGS7
    UniProtKB/TrEMBL
    A0A6P5QBF5
    Related
    ENSMUSP00000159090.2, ENSMUST00000238932.2
    Conserved Domains (1) summary
    pfam07264
    Location:120254
    EI24; Etoposide-induced protein 2.4 (EI24)
  2. NM_007915.6NP_031941.2  etoposide-induced protein 2.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC155921
    Consensus CDS
    CCDS22973.2
    UniProtKB/Swiss-Prot
    Q3UGS7
    UniProtKB/TrEMBL
    A0A6P5QBF5
    Related
    ENSMUSP00000132270.4, ENSMUST00000163192.11
    Conserved Domains (1) summary
    pfam07264
    Location:120254
    EI24; Etoposide-induced protein 2.4 (EI24)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    36690449..36708630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)