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Ehf ets homologous factor [ Mus musculus (house mouse) ]

Gene ID: 13661, updated on 24-Jan-2023

Summary

Official Symbol
Ehfprovided by MGI
Official Full Name
ets homologous factorprovided by MGI
Primary source
MGI:MGI:1270840
See related
Ensembl:ENSMUSG00000012350 AllianceGenome:MGI:1270840
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9030625L19Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in Golgi apparatus and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; female reproductive system; nasal epithelium; and urinary system. Orthologous to human EHF (ETS homologous factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 16.7), bladder adult (RPKM 11.7) and 10 other tissues See more
Orthologs
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Genomic context

See Ehf in Genome Data Viewer
Location:
2; 2 E2
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103093776..103133620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103263431..103303275, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene APAF1 interacting protein Neighboring gene predicted gene 13869 Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene cDNA sequence BC016548

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (7)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ETS homologous factor
Names
ETS domain-containing transcription factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007914.3NP_031940.1  ETS homologous factor

    See identical proteins and their annotated locations for NP_031940.1

    Status: VALIDATED

    Source sequence(s)
    AF035527, AK028651, BE134913, BX901906
    Consensus CDS
    CCDS16475.1
    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Related
    ENSMUSP00000087961.4, ENSMUST00000090475.10
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    103093776..103133620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498703.1XP_006498766.1  ETS homologous factor isoform X3

    See identical proteins and their annotated locations for XP_006498766.1

    Conserved Domains (2) summary
    smart00413
    Location:205292
    ETS; erythroblast transformation specific domain
    cl15755
    Location:39116
    SAM_superfamily; SAM (Sterile alpha motif )
  2. XM_006498699.1XP_006498762.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498762.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain
  3. XM_006498697.3XP_006498760.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498760.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Related
    ENSMUSP00000106805.2, ENSMUST00000111174.8
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain
  4. XM_006498698.4XP_006498761.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498761.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain
  5. XM_006498695.3XP_006498758.1  ETS homologous factor isoform X1

    See identical proteins and their annotated locations for XP_006498758.1

    Conserved Domains (2) summary
    cd08539
    Location:50127
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:217304
    ETS; erythroblast transformation specific domain
  6. XM_006498702.4XP_006498765.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498765.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain
  7. XM_006498701.4XP_006498764.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498764.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain
  8. XM_006498700.4XP_006498763.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498763.1

    UniProtKB/Swiss-Prot
    O70273, Q99K12
    UniProtKB/TrEMBL
    A0A8C6GJX5
    Conserved Domains (2) summary
    cd08539
    Location:39116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206293
    ETS; erythroblast transformation specific domain