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Ehf ets homologous factor [ Mus musculus (house mouse) ]

Gene ID: 13661, updated on 3-Jun-2018
Official Symbol
Ehfprovided by MGI
Official Full Name
ets homologous factorprovided by MGI
Primary source
MGI:MGI:1270840
See related
Ensembl:ENSMUSG00000012350 Vega:OTTMUSG00000014852
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AU019492; 9030625L19Rik
Expression
Biased expression in colon adult (RPKM 16.7), bladder adult (RPKM 11.7) and 10 other tissues See more
Orthologs
human all
See Ehf in Genome Data Viewer
Location:
2; 2 E2
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (103263431..103303275, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (103103590..103143353, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase complex, component X Neighboring gene APAF1 interacting protein Neighboring gene predicted gene 13869 Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene cDNA sequence BC016548

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Related articles in PubMed

  1. The Ets transcription factor EHF as a regulator of cornea epithelial cell identity. Stephens DN, et al. J Biol Chem, 2013 Nov 29. PMID 24142692, Free PMC Article
  2. Molecular cloning and expression of Ehf, a new member of the ets transcription factor/oncoprotein gene family. Bochert MA, et al. Biochem Biophys Res Commun, 1998 May 8. PMID 9600089
  3. BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Kumar R, et al. Clin Cancer Res, 2003 Aug 15. PMID 12960123
  4. Human chromosomal localization, tissue/tumor expression, and regulatory function of the ets family gene EHF. Kleinbaum LA, et al. Biochem Biophys Res Commun, 1999 Oct 14. PMID 10527851
  5. Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2. Choi YS, et al. Biochem J, 2006 Sep 15. PMID 16704374, Free PMC Article

See all (35) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
    Title: The Ets transcription factor EHF as a regulator of cornea epithelial cell identity.
Submit: New GeneRIF Correction

Genotypes

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding ISO
Inferred from Sequence Orthology
more info
  
DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
  
epithelial cell proliferation IEA
Inferred from Electronic Annotation
more info
  
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
  
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
Preferred Names
ETS homologous factor
Names
ETS domain-containing transcription factor
ehf

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007914.3 → NP_031940.1  ETS homologous factor

    See identical proteins and their annotated locations for NP_031940.1

    Status: VALIDATED

    Source sequence(s)
    AF035527, AK028651, BE134913, BX901906
    Consensus CDS
    CCDS16475.1
    UniProtKB/Swiss-Prot
    O70273
    Related
    ENSMUSP00000087961.3, OTTMUSP00000015775, ENSMUST00000090475.9, OTTMUST00000035278
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    103263431..103303275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498703.1 → XP_006498766.1  ETS homologous factor isoform X3

    See identical proteins and their annotated locations for XP_006498766.1

    Conserved Domains (2) summary
    smart00413
    Location:205 → 292
    ETS; erythroblast transformation specific domain
    cl15755
    Location:39 → 116
    SAM_superfamily; SAM (Sterile alpha motif )

  2. XM_006498699.1 → XP_006498762.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498762.1

    UniProtKB/Swiss-Prot
    O70273
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  3. XM_006498697.2 → XP_006498760.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498760.1

    UniProtKB/Swiss-Prot
    O70273
    Related
    ENSMUSP00000106805.1, OTTMUSP00000015776, ENSMUST00000111174.7, OTTMUST00000035279
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  4. XM_006498698.3 → XP_006498761.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498761.1

    UniProtKB/Swiss-Prot
    O70273
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  5. XM_006498695.3 → XP_006498758.1  ETS homologous factor isoform X1

    See identical proteins and their annotated locations for XP_006498758.1

    Conserved Domains (2) summary
    cd08539
    Location:50 → 127
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:217 → 304
    ETS; erythroblast transformation specific domain

  6. XM_006498702.3 → XP_006498765.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498765.1

    UniProtKB/Swiss-Prot
    O70273
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  7. XM_006498701.3 → XP_006498764.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498764.1

    UniProtKB/Swiss-Prot
    O70273
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

  8. XM_006498700.3 → XP_006498763.1  ETS homologous factor isoform X2

    See identical proteins and their annotated locations for XP_006498763.1

    UniProtKB/Swiss-Prot
    O70273
    Conserved Domains (2) summary
    cd08539
    Location:39 → 116
    SAM_PNT-ESE-3-like; Sterile alpha motif (SAM)/Pointed domain of ESE-3 like ETS transcriptional regulators
    smart00413
    Location:206 → 293
    ETS; erythroblast transformation specific domain

Reference GRCm38.p4 129S1/SvImJ

Genomic

  1. NT_039223.3 Reference GRCm38.p4 129S1/SvImJ

    Range
    285339..325167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70273.1 GenPept UniProtKB/Swiss-Prot:O70273

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