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Egr2 early growth response 2 [ Mus musculus (house mouse) ]

Gene ID: 13654, updated on 7-Jan-2023

Summary

Official Symbol
Egr2provided by MGI
Official Full Name
early growth response 2provided by MGI
Primary source
MGI:MGI:95296
See related
Ensembl:ENSMUSG00000037868 AllianceGenome:MGI:95296
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Egr-2; Zfp-6; Krox20; NGF1-B; Zfp-25; Krox-20
Summary
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and SUMO ligase activity. Involved in several processes, including nervous system development; positive regulation of myelination; and protein sumoylation. Acts upstream of or within several processes, including nervous system development; regulation of ossification; and skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in several structures, including genitourinary system; head mesenchyme derived from neural crest; nervous system; neural ectoderm; and vibrissa. Used to study Charcot-Marie-Tooth disease type 4E. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 1D; Charcot-Marie-Tooth disease type 3; Charcot-Marie-Tooth disease type 4E; and motor peripheral neuropathy. Orthologous to human EGR2 (early growth response 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 22.3), thymus adult (RPKM 4.2) and 14 other tissues See more
Orthologs
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Genomic context

See Egr2 in Genome Data Viewer
Location:
10 B5.1; 10 34.96 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (67370334..67383354)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (67534469..67542188)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32255 Neighboring gene predicted gene, 40679 Neighboring gene predicted gene, 32176 Neighboring gene 2-aminoethanethiol (cysteamine) dioxygenase Neighboring gene RIKEN cDNA 4930563J15 gene Neighboring gene predicted gene, 32364 Neighboring gene predicted gene, 32515

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (13)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables HMG box domain binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to organic substance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within facial nerve structural organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in facial nerve structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within_negative_effect gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Schwann cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ossification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to insulin ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhombomere 3 development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within rhombomere 3 formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhombomere 3 structural organization IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rhombomere 5 formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rhombomere 5 structural organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in rhombomere 5 structural organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic behavior IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within rhythmic behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 SUMO-protein ligase EGR2
Names
E3 SUMO-protein transferase ERG2
early growth response protein 2
zinc finger protein Krox-20
NP_001334387.1
NP_001360912.1
NP_001360914.1
NP_001360915.1
NP_001360916.1
NP_034248.2
XP_030100730.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347458.1NP_001334387.1  E3 SUMO-protein ligase EGR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK155585, BP753840, BY209001
    Consensus CDS
    CCDS83706.1
    UniProtKB/Swiss-Prot
    P08152
    UniProtKB/TrEMBL
    Q3U207
    Conserved Domains (4) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44116
    DUF3446; Domain of unknown function (DUF3446)
  2. NM_001373983.1NP_001360912.1  E3 SUMO-protein ligase EGR2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC153379
    UniProtKB/TrEMBL
    A0A8C6IHD2
    Conserved Domains (4) summary
    COG5048
    Location:378434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:350374
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:107179
    DUF3446; Domain of unknown function (DUF3446)
  3. NM_001373985.1NP_001360914.1  E3 SUMO-protein ligase EGR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153379
    Consensus CDS
    CCDS83706.1
    Conserved Domains (4) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44116
    DUF3446; Domain of unknown function (DUF3446)
  4. NM_001373986.1NP_001360915.1  E3 SUMO-protein ligase EGR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153379
    Consensus CDS
    CCDS83706.1
    Conserved Domains (4) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44116
    DUF3446; Domain of unknown function (DUF3446)
  5. NM_001373987.1NP_001360916.1  E3 SUMO-protein ligase EGR2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC153379
    Consensus CDS
    CCDS83706.1
    Related
    ENSMUSP00000101078.3, ENSMUST00000105438.9
    Conserved Domains (4) summary
    COG5048
    Location:315371
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:289311
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:287311
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:44116
    DUF3446; Domain of unknown function (DUF3446)
  6. NM_010118.3NP_034248.2  E3 SUMO-protein ligase EGR2 isoform 1

    See identical proteins and their annotated locations for NP_034248.2

    Status: VALIDATED

    Source sequence(s)
    AK155585, BY742929, X06746
    Consensus CDS
    CCDS35927.2
    UniProtKB/Swiss-Prot
    P08152
    UniProtKB/TrEMBL
    Q3U207
    Related
    ENSMUSP00000041053.8, ENSMUST00000048289.14
    Conserved Domains (5) summary
    COG5048
    Location:365421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:339361
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:337361
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:94166
    DUF3446; Domain of unknown function (DUF3446)
    pfam13465
    Location:381406
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    67370334..67383354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244870.2XP_030100730.1  E3 SUMO-protein ligase EGR2 isoform X1

    UniProtKB/TrEMBL
    A0A8C6IHD2
    Conserved Domains (4) summary
    COG5048
    Location:378434
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:352374
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:350374
    zf-C2H2; Zinc finger, C2H2 type
    pfam11928
    Location:107179
    DUF3446; Domain of unknown function (DUF3446)