Format

Send to:

Choose Destination

Klk1b9 kallikrein 1-related peptidase b9 [ Mus musculus (house mouse) ]

Gene ID: 13648, updated on 23-Jun-2021

Summary

Official Symbol
Klk1b9provided by MGI
Official Full Name
kallikrein 1-related peptidase b9provided by MGI
Primary source
MGI:MGI:95293
See related
Ensembl:ENSMUSG00000059042
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAL; Klk; Klk9; Egfbp; mGk-9; Egfbp-; Egfbp3; Egfbp-3; EGF-BP C; kallikrein
Summary
This gene encodes a member of the kallikrein subfamily of serine proteases that are involved in diverse physiological functions such as skin desquamation, tooth enamel formation, seminal liquefaction, synaptic neural plasticity and brain function. The encoded preproprotein undergoes proteolytic cleavage of the activation peptide to generate the functional enzyme. This gene is located in a cluster of several related kallikrein genes on chromosome 7. [provided by RefSeq, Feb 2016]
Expression
Biased expression in testis adult (RPKM 7.6), kidney adult (RPKM 1.0) and 1 other tissue See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Klk1b9 in Genome Data Viewer
Location:
7 B3; 7 28.45 cM
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43625485..43629800)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43976061..43980376)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (51231431..51235746)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene kallikrein 1-related peptidase b2, pseudogene Neighboring gene kallikrein 1-related peptidase b1 Neighboring gene kallikrein 1-related peptidase b10, pseudogene Neighboring gene kallikrein 1-related peptidase b11

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of systemic arterial blood pressure IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within zymogen activation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein 1-related peptidase b9
Names
epidermal growth factor-binding protein type C
glandular kallikrein K9
tissue kallikrein-9
NP_034246.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010116.1NP_034246.1  kallikrein 1-related peptidase b9 preproprotein

    See identical proteins and their annotated locations for NP_034246.1

    Status: REVIEWED

    Source sequence(s)
    M17962
    Consensus CDS
    CCDS21191.1
    UniProtKB/Swiss-Prot
    P15949
    Related
    ENSMUSP00000080133.4, ENSMUST00000081399.4
    Conserved Domains (2) summary
    smart00020
    Location:24253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:25256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43625485..43629800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center