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Egf epidermal growth factor [ Mus musculus (house mouse) ]

Gene ID: 13645, updated on 23-May-2018
Official Symbol
Egfprovided by MGI
Official Full Name
epidermal growth factorprovided by MGI
Primary source
MGI:MGI:95290
See related
Ensembl:ENSMUSG00000028017 Vega:OTTMUSG00000054128
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI790464
Summary
This gene encodes epidermal growth factor (EGF), the founding member of the EGF family of growth factors that are implicated in cell proliferation and differentiation. The encoded protein can localize to the membrane and function in juxtacrine signaling or undergo proteolytic processing to generate a soluble form of the hormone. Mice lacking the encoded protein do not exhibit an abnormal phenotype but transgenic mice overexpressing the encoded protein exhibit hypospermatogenesis. [provided by RefSeq, Jul 2016]
Expression
Restricted expression toward kidney adult (RPKM 187.5) See more
Orthologs
See Egf in Genome Data Viewer
Location:
3 G3; 3 58.5 cM
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (129677574..129755439, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (129380493..129458240, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7A, pseudogene 7 Neighboring gene predicted gene, 35986 Neighboring gene ELOVL family member 6, elongation of long chain fatty acids (yeast) Neighboring gene RIKEN cDNA 6330410L21 gene Neighboring gene predicted gene, 36130 Neighboring gene leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 Neighboring gene retinal pigment epithelium derived rhodopsin homolog

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
epidermal growth factor receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway involved in dorsal/ventral axis specification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of MAPK activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKK activity IDA
Inferred from Direct Assay
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
branching morphogenesis of an epithelial tube IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermal growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
mammary gland alveolus development IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of cholesterol efflux IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of secretion ISO
Inferred from Sequence Orthology
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cerebellar granule cell precursor proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of epidermal growth factor-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of hyaluronan biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitotic nuclear division ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
regulation of protein transport ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Preferred Names
pro-epidermal growth factor
Names
Pro-epidermal growth factor precursor (EGF)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310737.1NP_001297666.1  pro-epidermal growth factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC098732, AK136439, AK157778, BP761200
    Consensus CDS
    CCDS80020.1
    UniProtKB/TrEMBL
    A0A0G2JF92, Q3UWD7
    Related
    ENSMUSP00000143075.1, OTTMUSP00000071665, ENSMUST00000197079.4, OTTMUST00000135432
    Conserved Domains (5) summary
    PHA02887
    Location:481518
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:95138
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam07001
    Location:609700
    BAT2_N; BAT2 N-terminus
    pfam07645
    Location:376416
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:250285
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. NM_001329594.1NP_001316523.1  pro-epidermal growth factor isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC098732, AK085707, BB635280, BP761200
    UniProtKB/TrEMBL
    A0A0G2JDT8
  3. NM_010113.4NP_034243.2  pro-epidermal growth factor isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_034243.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC098732, AK136439, BP761200
    Consensus CDS
    CCDS17833.1
    UniProtKB/Swiss-Prot
    P01132
    UniProtKB/TrEMBL
    Q3UWD7
    Related
    ENSMUSP00000029653.2, OTTMUSP00000071300, ENSMUST00000029653.6, OTTMUST00000134475
    Conserved Domains (5) summary
    PHA02887
    Location:9821019
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:596639
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam07645
    Location:877917
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:449482
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:358399
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

    Range
    129677574..129755439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240011.2XP_011238313.1  pro-epidermal growth factor isoform X2

    Conserved Domains (4) summary
    PHA02887
    Location:945982
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:600643
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam07645
    Location:881921
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:370405
    FXa_inhibition; Coagulation Factor Xa inhibitory site
  2. XM_011240010.2XP_011238312.1  pro-epidermal growth factor isoform X1

    Conserved Domains (5) summary
    PHA02887
    Location:9861023
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:600643
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam07645
    Location:881921
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:453486
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:362403
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
  3. XM_006500990.3XP_006501053.1  pro-epidermal growth factor isoform X3

    Conserved Domains (4) summary
    PHA02887
    Location:941978
    PHA02887; EGF-like protein; Provisional
    smart00135
    Location:596639
    LY; Low-density lipoprotein-receptor YWTD domain
    pfam07645
    Location:877917
    EGF_CA; Calcium-binding EGF domain
    pfam14670
    Location:366401
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RNA

  1. XR_001783650.1 RNA Sequence

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