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Efna5 ephrin A5 [ Mus musculus (house mouse) ]

Gene ID: 13640, updated on 13-Feb-2024

Summary

Official Symbol
Efna5provided by MGI
Official Full Name
ephrin A5provided by MGI
Primary source
MGI:MGI:107444
See related
Ensembl:ENSMUSG00000048915 AllianceGenome:MGI:107444
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AL-1; Epl7; RAGS; EFL-5; LERK-7; Ephrin-A5
Summary
Enables chemorepellent activity; ephrin receptor binding activity; and neurotrophin TRKB receptor binding activity. Involved in several processes, including ephrin receptor signaling pathway; positive regulation of nervous system development; and synaptic membrane adhesion. Acts upstream of or within cellular response to follicle-stimulating hormone stimulus; cellular response to forskolin; and retinal ganglion cell axon guidance. Located in adherens junction; basement membrane; and plasma membrane. Is active in GABA-ergic synapse. Is expressed in several structures, including alimentary system; central nervous system; embryo ectoderm; limb; and sensory organ. Used to study anencephaly. Orthologous to human EFNA5 (ephrin A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 7.2), limb E14.5 (RPKM 6.9) and 21 other tissues See more
Orthologs
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Genomic context

See Efna5 in Genome Data Viewer
Location:
17 E1.1; 17 32.57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (62909949..63188431, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (62602957..62881317, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42959 Neighboring gene predicted gene, 52291 Neighboring gene STARR-seq mESC enhancer starr_42960 Neighboring gene predicted gene, 25800 Neighboring gene STARR-seq mESC enhancer starr_42963 Neighboring gene VISTA enhancer mm1538 Neighboring gene predicted gene, 52303 Neighboring gene predicted gene, 46583 Neighboring gene STARR-seq mESC enhancer starr_42966 Neighboring gene STARR-seq mESC enhancer starr_42967 Neighboring gene predicted gene, 34179 Neighboring gene predicted gene, 34324 Neighboring gene F-box and leucine-rich repeat protein 17

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables neurotrophin TRKB receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to follicle-stimulating hormone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to forskolin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in collateral sprouting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ephrin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of collateral sprouting IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in regulation of cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within retinal ganglion cell axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic membrane adhesion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in synaptic membrane adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synaptic membrane adhesion IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in GABA-ergic synapse IPI
Inferred from Physical Interaction
more info
PubMed 
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ephrin-A5
Names
EPH-related receptor tyrosine kinase ligand 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413234.1NP_001400163.1  ephrin-A5 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134243, AC154385
  2. NM_010109.4NP_034239.1  ephrin-A5 isoform 2 precursor

    See identical proteins and their annotated locations for NP_034239.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC134243, AC154385
    Consensus CDS
    CCDS28934.1
    UniProtKB/Swiss-Prot
    O08543
    Related
    ENSMUSP00000077883.5, ENSMUST00000078839.5
    Conserved Domains (1) summary
    cd10425
    Location:30159
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A
  3. NM_207654.3NP_997537.1  ephrin-A5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_997537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC134243, AC154385
    Consensus CDS
    CCDS28935.1
    UniProtKB/Swiss-Prot
    O08543, O08544
    Related
    ENSMUSP00000076115.6, ENSMUST00000076840.12
    Conserved Domains (1) summary
    cd10425
    Location:30159
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    62909949..63188431 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)