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Efna4 ephrin A4 [ Mus musculus (house mouse) ]

Gene ID: 13639, updated on 26-Sep-2022

Summary

Official Symbol
Efna4provided by MGI
Official Full Name
ephrin A4provided by MGI
Primary source
MGI:MGI:106643
See related
Ensembl:ENSMUSG00000028040 AllianceGenome:MGI:106643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epl4; EFL-4; LERK-4
Summary
Predicted to enable ephrin receptor binding activity. Predicted to be involved in axon guidance and ephrin receptor signaling pathway. Predicted to be located in membrane. Predicted to be anchored component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and thymus. Orthologous to human EFNA4 (ephrin A4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 20.7), ovary adult (RPKM 14.7) and 18 other tissues See more
Orthologs
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Genomic context

See Efna4 in Genome Data Viewer
Location:
3 F1; 3 39.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89240700..89245335, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89333393..89338028, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene ephrin A3 Neighboring gene predicted gene 15998 Neighboring gene predicted gene, 34118 Neighboring gene a disintegrin and metallopeptidase domain 15 (metargidin) Neighboring gene DC-STAMP domain containing 1 Neighboring gene DC-STAMP domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ephrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ephrin-A4
Names
EPH-related receptor tyrosine kinase ligand 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007910.2NP_031936.2  ephrin-A4 precursor

    See identical proteins and their annotated locations for NP_031936.2

    Status: VALIDATED

    Source sequence(s)
    AA764182, AK012195, AK142604, BB472066
    Consensus CDS
    CCDS38489.1
    UniProtKB/Swiss-Prot
    O08542, O55218
    UniProtKB/TrEMBL
    Q3UQB5, Q9CZS8
    Related
    ENSMUSP00000029674.8, ENSMUST00000029674.8
    Conserved Domains (1) summary
    cd10425
    Location:27155
    Ephrin-A_Ectodomain; Ectodomain of Ephrin A

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89240700..89245335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)